Evidence map›Paper›PMID 41088554›Full record

ArticleMagnetic resonance in medicine2026

Quantification of Tryptophan and NAD

Sophia Swago, Neil E Wilson, Mark A Elliott, Ravinder Reddy, Walter R Witschey, Ravi Prakash Reddy Nanga

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Quantification of Tryptophan and NADMagnetic resonance in medicine · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sophia SwagoDepartment of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-8334-4746
Neil E WilsonDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0009-0002-7766-2929
Mark A ElliottDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ravinder ReddyDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Walter R WitscheyDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-1669-2120
Ravi Prakash Reddy NangaDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-3644-5656

Funding

High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
Imaging of glutamatergic system changes in Alzheimer's disease in vivoR01AG063869 · NIA · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2020 to 2024
$3.0M
Non-invasive imaging of reactive oxygen species in reperfusion injury myocardial infarctionR01HL169378 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACO E. BRAVO, Walter R.T. Witschey · 2023 to 2026
$3.0M
Cardiac MR imaging of hemorrhagic reperfusion injury after myocardial infarctionR01HL137984 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WITSCHEY, WALTER R.T. · 2018 to 2022
$2.8M
Novel Imaging Biomarkers of Lipid and Ketone Metabolism in Alzheimer's DiseaseRF1AG087306 · NIA · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2024 to 2024
$2.1M
Cardiac 1H MRS assessment of NAD+ after Tetralogy of Fallot repairF31HL158217 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SWAGO, SOPHIA · 2021 to 2023
$140k
NHLBI NIH HHS F31 HL158217NHLBI NIH HHS F31HL158217NHLBI NIH HHS R01 HL137984NHLBI NIH HHS R01HL137984NHLBI NIH HHS R01 HL169378NHLBI NIH HHS R01HL169378NIA NIH HHS R01 AG063869NIA NIH HHS R01AG063869NIA NIH HHS RF1 AG087306NIA NIH HHS RF1AG087306NIBIB NIH HHS P41 EB029460NIBIB NIH HHS P41EB029460
6 · The paper itself

Abstract

purposeThe purpose of this study was to investigate the effect of magnetization exchange on the measurement of tryptophan and NAD

methodsWe collected downfield

resultsThe apparent T

conclusionTryptophan chemical exchange and NAD

Indexed as

BrainNADProton Magnetic Resonance SpectroscopyTryptophanAdultFemaleHumansMaleReproducibility of ResultsYoung AdultNADTryptophanbrainchemical exchangecross‐relaxationdownfield spectroscopymagnetic resonance spectroscopyspectral excitationT1 relaxation time

Identifiers

PMID41088554
PMCPMC12746366

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.