Evidence map›Paper›PMID 41088546›Full record

ArticlePsycho-oncology2025

Distinguishing Mental From Physical Fatigue in Patients With Low-Grade Glioma.

Femke F Siebenga, Sandra E Rakers, Floor Gelmers, Hiska L van der Weide, Miranda C A Kramer, Anouk van der Hoorn, Roelien H Enting, Ingeborg Bosma, Rob J M Groen, Hanne-Rinck Jeltema and 3 more

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Article in Psycho-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Femke F SiebengaDepartment of Neurology, Unit of Neuropsychology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0009-0004-9307-7994
Sandra E RakersDepartment of Neurology, Unit of Neuropsychology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Floor GelmersDepartment of Neurology, Unit of Neuropsychology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Hiska L van der WeideDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Miranda C A KramerDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Anouk van der HoornDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Roelien H EntingDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Ingeborg BosmaDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Rob J M GroenDepartment of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Hanne-Rinck JeltemaDepartment of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Michiel WagemakersDepartment of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Jacoba M SpikmanDepartment of Neurology, Unit of Neuropsychology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Anne M BuunkDepartment of Neurology, Unit of Neuropsychology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFatigue is a common consequence of low-grade gliomas (LGG), but its specific nature has not been extensively studied. In particular, it remains unclear if the prevalence and determinants of mental fatigue differ from those of physical fatigue. Therefore, this study aimed to examine (1) whether the prevalence and severity of mental fatigue differ from physical fatigue in patients with LGG; (2) the specific determinants of mental and physical fatigue, including cognitive impairments, affective symptoms and radiological abnormalities.

methodsA total of 148 patients with LGG were included and assessed with the Dutch Multifactor Fatigue Scale (DMFS; mental and physical fatigue) and the Hospital Anxiety and Depression Scale (HADS; affective symptoms). Neuropsychological tests were administered to measure cognitive impairments, particularly in basic and complex information processing speed.

resultsSevere mental fatigue affected 38% of patients, a significantly different prevalence than that of severe physical fatigue (22%), with an overlap of 15%. Patients with severe mental fatigue had significantly lower scores on a divided attention task, compared to patients with non-severe mental fatigue. In a hierarchical linear prediction model with demographical, radiological and psychological variables, different sets of determinants were found for mental fatigue (anxiety and depression) and physical fatigue (depression, educational level and tumor volume).

conclusionsMental fatigue can be distinguished from physical fatigue in patients with LGG, characterized by a high prevalence and unique determinants. Therefore, mental fatigue should be considered as a distinct construct and presumably requires a different (neuro)psychological therapeutic approach compared to physical fatigue.

Indexed as

Brain NeoplasmsFatigueGliomaMental FatigueAdultAgedAnxietyCognition DisordersDepressionFemaleHumansMaleMiddle AgedNeuropsychological TestsPrevalenceSeverity of Illness Indexaffective symptomscognitive impairmentslow‐grade gliomamental fatiguephysical fatigue

Identifiers

PMID41088546
PMCPMC12521796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.