ArticleHelicobacter
A Three-Way Comparison of Nodular Lesions in H. pylori-Induced Gastritis, Non-Helicobacter pylori Helicobacter (NHPH)-Induced Gastritis, and NHPH-Induced MALT Lymphoma Reveals Their Distinct Endoscopic Predictors: Distribution for Bacterial Etiology and Morphology for Malignancy.
Article in Helicobacter. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNodular gastritis associated with Helicobacter pylori infection (HPi-NG) has long been recognized. Recently, similar mucosal changes have been reported with non-H. pylori Helicobacter (NHPH), including NHPH-induced gastric mucosa-associated lymphoid tissue lymphoma with a nodular gastritis-like appearance (NHPHi-MNG) and NHPH-induced nodular gastritis (NHPHi-NG). However, how bacterial species differences and the presence or absence of malignancy are reflected in endoscopic appearance has not been sufficiently investigated. This study aimed to clarify these relationships and to identify key endoscopic features that differentiate among the three clinically distinct entities.
methodsWe retrospectively analyzed 69 patients diagnosed at Hiroshima University Hospital between 2013 and 2024: 11 with NHPHi-MNG, 12 with NHPHi-NG, and 46 with HPi-NG. Endoscopic findings were compared, focusing on three morphological features of the nodules (maximum diameter, size heterogeneity, and shape) and three distributional features (extent of nodularity, extension to the lower gastric body, and predominant site of nodularity), along with patient sex. Diagnostic accuracy was calculated based on combinations of these features.
resultsNHPHi-MNG was differentiated from NHPHi-NG with 91.3% accuracy when two or more of the three morphological criteria were satisfied. NHPHi-MNG was distinguished from HPi-NG with 93.0% accuracy when four or more of seven criteria were fulfilled: the three morphological features, three distributional features, and patient sex. NHPHi-NG was differentiated from HPi-NG with 91.4% accuracy when all three distributional features were present.
conclusionAmong the three nodular gastric conditions, the morphological features of nodules reflected the presence or absence of malignancy, whereas the distributional features were associated with the underlying bacterial species. These findings suggest that specific endoscopic features can aid in distinguishing between benign and malignant forms of nodular gastric lesions and between infections with different Helicobacter species, providing important diagnostic guidance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.