ArticleMagnetic resonance in medicine2026
Inverting CEST or
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Inverting CEST orMagnetic resonance in medicine · 2026Article
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Authors and funding
1 author.
Funding
Abstract
purposeThe goal of CEST imaging is to reveal the underlying tissue composition and exchange. However, quantitative CEST analyses typically require strong assumptions about this same composition and exchange. The goal of this paper is to introduce a new CEST analysis (also applicable to rotating frame relaxation rate THEORY AND
methodsEach exchanging solute adds an additional term to
resultsThe simulation and experimental results demonstrate the ability to qualitatively characterize the number of exchanging solutes, their offsets, and their exchange rates, and to do so under difficult fitting conditions such as when multiple solutes are at the same frequency offset. This signal inversion is only grossly accurate and has significant biases, limited range of applicability, and spurious results.
conclusionAn inversion of the CEST signal is demonstrated that requires minimal assumptions and can qualitatively characterize the distribution of contributing solutes. These results demonstrate proof of concept, but further work is needed to address in vivo conditions, optimize acquisition and analysis methods, and determine trade-offs between sensitivity, accuracy, range of applicability, and prevalence of fitting artifacts. The ultimate ability of the method to characterize the full range of exchanging solutes in vivo is not yet clear.
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