Evidence map›Paper›PMID 41088488›Full record

ArticleJournal of anesthesia, analgesia and critical care2025

Exploring risk factors for pediatric cancer patients admitted to the Pediatric Intensive Care Unit: insight from a multicenter observational study revealing no association with mechanical ventilation.

Angela Amigoni, Sara Boscato, Maria Cristina Mondardini, Francesca Cavagnero, Luca Marchetto, Veronica Biassoni, Carolina Birolo, Gabriella Bottari, Manuela Corno, Stefania Ferrario and 13 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of anesthesia, analgesia and critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04581655 (Retrospective and Prospective Analysis of Risk and Outcome Factors in Oncohematological Patients Admitted to Italian Pediatric Intensive Care Units), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04581655 completednot on this map

Retrospective and Prospective Analysis of Risk and Outcome Factors in Oncohematological Patients Admitted to Italian Pediatric Intensive Care Units: a Multicenter Study

TypeobservationalSponsorAzienda Ospedaliera di PadovaRan2021 to 2022Enrolled500ConditionsPediatric Cancer, Critically Ill
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Angela AmigoniPediatric Intensive Care Unit, Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy.
Sara BoscatoUniversity of Padua, Padua, Italy.
Maria Cristina MondardiniPediatric Intensive Care Unit, IRCCS AOUBO, Via Albertoni 15, Bologna, 40138, Italy. mariacristina.mondardini@aosp.bo.it.
Francesca CavagneroPediatric Intensive Care Unit, Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy.
Luca MarchettoPediatric Intensive Care Unit, Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy.
Veronica BiassoniPediatric Oncologic Unit, Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy.
Carolina BiroloS. Bortolo Hospital, Vicenza, Italy.
Gabriella BottariDEA Unit, Bambino Gesù Chidren's Hospital, Rome, Italy.
Manuela CornoPapa Giovanni, XXIII Hospital, Bergamo, Italy.
Stefania FerrarioBuzzi Children's Hospital, Milan, Italy.
Giorgia MaioloAOU Città Della Salute E Della Scienza, Regina Margherita Hospital, Turin, Italy.
Alessia MontagutiNeonatal and Pediatric Intensive Care Unit, Emergency Department, IRCCS Giannina Gaslini Children's Hospital, Genoa, Italy.
Emanuele RossettiARCO Unit, Bambino Gesù Children's Hospital, Rome, Italy.
Immacolata RulliTerapia Intensiva Neonatale E Pediatrica, University Hospital Policlinico G. Martino, Messina, Italy.
Raffaella SagrediniBurlo Garofalo Hospital, Trieste, Italy.
Stefania SpaggiariUniversity Hospital of Verona, Verona, Italy.
Luisa VatieroMeyer Children's Hospital, Florence, Italy.
Gianluca VignaSpedali Civili, Brescia, Italy.
Matteo MartinatoUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Dario GregoriUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Marta PillonPediatric Oncologic Unit, University Hospital of Padua, Padua, Italy.
Rosanna Irene ComorettoDepartment of Sciences of Public Health and Pediatrics, University of Turin, Turin, Italy.
OncoTIPNet Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo analyze risk factors for adverse outcomes in a nationally representative sample of pediatric cancer patients admitted to the PICU.

methodsAn observational study composed of a 2-year retrospective phase and a 2-year prospective phase was conducted before and during PICU admission in Italian PICUs.

resultsWe included 518 patients, median age 7.2 years (IQR 2.5-12.6). Main diagnosis: solid tumors (51%) and acute lymphoblastic leukemia (23%). Nineteen percent underwent stem cell transplantation (HSCT). Main causes of admission were respiratory failure (33%) and neurological impairment (24%). In-PICU mortality was 15%, higher in HSCT (41%) and non-solid cancer (25%). Pre-PICU mortality risk factors included HSCT (OR 3.48, 95%CI 1.5-8.11), higher Pediatric Overall Performance Category (POPC) (OR 1.72, 95%CI 1.23-2.42), and Pediatric Index of Mortality 3 (PIM-3) score (OR 1.03, 95%CI 1.01-1.06). In-PICU mortality risk factors included multiple organ failure (MOF) (OR 4.83, 95%CI 1.66-15.71), and cardiac arrest (OR 82.16, 95%CI 14.19-1594.61). The use of MV does not appear to be associated with increased mortality. Longer PICU LOS was associated with pre-admission acute respiratory distress syndrome (p < 0.001), renal failure (p = 0.024), POPC (p = 0.007) and PIM 3 (p < 0.001), and in-PICU use of total parenteral nutrition (p = 0.036), and duration of mechanical ventilation (MV) (p < 0.001).

conclusionsHSCT, non-solid tumor, higher PIM-3, and POPC on admission, MOF, and history of cardiac arrest were associated with poorer outcome. The use of MV does not appear to be associated with increased mortality.

trial registrationClinicalTrials.gov ID NCT04581655, October 7, 2020.

Indexed as

CancerIntensive care unitsOutcomesPediatricRisk factors

Identifiers

PMID41088488
PMCPMC12522403

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.