SynthesisSystematic reviews2025
Relationship between stroke injury sites and incidence of post-stroke pain: a systematic review and meta-analysis.
Synthesis in Systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundPost-stroke pain (PSP) is a prevalent and debilitating complication of stroke recovery, mainly characterized by allodynia and hyperalgesia. While certain brain lesion sites, particularly thalamic lesions, have been implicated in an increased risk of PSP, evidence regarding the specific contributions of stroke injury sites to PSP development remains inconsistent. This meta-analysis aimed to synthesize available data on the relationship between stroke lesion sites and PSP incidence, providing a more detailed understanding to inform clinical management.
methodsA systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Literature searches were performed across four major databases, including Embase, Scopus, Web of Science, and PubMed, up to December 31, 2024. Studies were included if they assessed the association between stroke lesion sites and PSP and reported 95% confidence intervals (CIs) for relevant outcomes. A random-effects model was used to pool incidence estimates, and heterogeneity across studies was evaluated. Subgroup analyses were conducted based on different PSP subtypes, including post-stroke shoulder pain (PSSP) and central post-stroke pain (CPSP).
resultsFrom an initial pool of 14,631 screened studies, 25 met the eligibility criteria, involving a total of 3,812 stroke patients. The meta-analysis revealed a higher incidence of PSP (49% [95% CI: 0.41-0.56]) in patients with left-sided cerebral stroke compared to those with right-sided stroke. Subgroup analyses indicated significant associations between left-sided stroke lesions and both PSSP (50% [95% CI: 0.39-0.61]) and CPSP (41% [95% CI: 0.37-0.45]). Additionally, thalamic lesions were significantly associated with PSP in 36% (95% CI: 0.17-0.58) of cases. Despite some heterogeneity (I
conclusionsThis meta-analysis provided significant association between left-sided cerebral stroke and the increased incidence of PSP, particularly in patients with PSSP and CPSP. Thalamic stroke was notably associated with the development of PSP. These results underscore the importance of considering stroke injury sites in the assessment and management of PSP during stroke rehabilitation. Recognizing these associations can aid in the development of targeted therapeutic strategies, ultimately improving stroke patients' outcomes and quality of life. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019139928.
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