Evidence map›Paper›PMID 41088422›Full record

ArticleAnnals of general psychiatry2025

Discrimination of first-onset patients with bipolar disorder or major depressive disorder using screened biochemical parameters.

Yuncheng Zhu, Sheng Li, Ju Gao, Fang Wang, Ni Zhou, Chuangxin Wu, Xiaojia Huang, Ningning Li, Xiaohui Wu, Hongmei Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of general psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Peripheral S-(PGJBMC psychiatry · 2026
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

14 authors.

Yuncheng ZhuClinical Research Center & Division of Mood Disorders, Shanghai Hongkou Mental Health Center, Shanghai, 200434, China.ORCID http://orcid.org/0000-0003-4686-8887
Sheng Li *Shanghai Changning Mental Health Center, Affiliated Mental Health Center of East China Normal University, Shanghai, 200335, China.
Ju Gao *Suzhou Psychiatric Hospital, Institute of Mental Health, The Affiliated Guangji Hospital of Soochow University, Suzhou, 215006, China.
Fang WangMental Health Center, Shanghai University of Medicine & Health Sciences, Shanghai, 200093, China. wangfangpsychiatry@163.com.
Ni ZhouClinical Research Center & Division of Mood Disorders, Shanghai Hongkou Mental Health Center, Shanghai, 200434, China.
Chuangxin WuClinical Research Center & Division of Mood Disorders, Shanghai Hongkou Mental Health Center, Shanghai, 200434, China.
Xiaojia HuangClinical Research Center & Division of Mood Disorders, Shanghai Hongkou Mental Health Center, Shanghai, 200434, China.
Ningning LiClinical Research Center & Division of Mood Disorders, Shanghai Hongkou Mental Health Center, Shanghai, 200434, China.
Xiaohui WuClinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Hongmei LiuClinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Lu YangClinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Xiaoyun GuoClinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Zuowei WangClinical Research Center & Division of Mood Disorders, Shanghai Hongkou Mental Health Center, Shanghai, 200434, China.
Yiru FangDepartment of Psychiatry & Affective Disorders Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. yirufang@aliyun.com.ORCID http://orcid.org/0000-0002-8748-9085

Funding

Doctoral Talent Program of Suzhou Guangji Hospital 2022B01Excellent Talent Training Program of Shanghai Hongkou Mental Health Center 2023XKDTR01Health System Key Discipline of Shanghai 2024ZDXK0013National Key Research and Development Program of China 2016YFC1307100Scientific Research Project of Hongkou District Health Commission 2401-06
6 · The paper itself

Abstract

backgroundTheoretical hypotheses suggest differing oxidative stress levels in mood disorders. We evaluated eight oxidative stress-related biochemical markers for further verification in first-onset patients with bipolar disorder (BD) or major depressive disorder (MDD).

methodsWe extracted 224 first-onset patients (BD = 93 and MDD = 131) from the overall sample database of 4647 candidates. And we analyzed eight parameters: direct bilirubin (DBIL), indirect bilirubin (IBIL), uric acid (UA), lactate dehydrogenase (LDH), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), prealbumin, and progesterone.The above parameters enter the hierarchical multiple linear regression model for analysis.

resultsWhen compared to MDD, the BD group showed decreased prealbumin and elevated UA, LDH, and FT3 in males while decreased prealbumin and DBIL and elevated IDBIL, LDH, FT3 and progesterone in females (p's < 0.05). The model effectively differentiated between BD and MDD, achieving AUCs of 0.894 for men and 0.897 for women.

conclusionThis result elucidates the validity of these biomarkers for identifying first-episode patients with BD or MDD. The discrimination was satisfactory, with good diagnostic accuracy for both gender subgroups.

Indexed as

Biological markersBipolar disorderFirst onsetMajor depressive disorder

Identifiers

PMID41088422
PMCPMC12519812

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