Evidence map›Paper›PMID 41088418›Full record

ReviewStem cell research & therapy2025

Cholesterol metabolism on stem cell fate determination: a frontier horizon.

Boyang Xu, Ling Li, Qian Wei, Yuli Wang, He Huang, Tao Pang, Zhijian Wei, Guoqing Zheng, Yue Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. High-Fat Diet Remodels Plasma Membrane Rigidity to Potentiate Colonocyte Stemness in Mice.Cellular and molecular gastroenterology and hepatology · 2026
    Article
  2. Review
  3. Starve-Feed Cycles Direct Quiescence to Proliferation Transitions inbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Boyang XuState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China.
Ling LiSchool of Pharmacy, Meishan Pharmaceutical Vocational College, Meishan, Sichuan, 620200, China.
Qian WeiGansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, 730050, China.
Yuli WangDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, 21218, USA.
He HuangSchool of Synthetic Biology and Biomanufacturing, State Key Laboratory of Synthetic Biology, Key Laboratory of Biological and Pharmaceutical Engineering, Tianjin University, Tianjin, 300350, China.
Tao PangState Key Laboratory of Natural Medicines, New Drug Screening and Pharmacodynamics Evaluation Center, China Pharmaceutical University, Nanjing, 210009, China. tpang@cpu.edu.cn.
Zhijian WeiDepartment of Orthopaedics, Advanced Medical Research Institute, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Shandong University, Jinan, Shandong, 250012, China. weizhijian2002@126.com.
Guoqing ZhengDepartment of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China. gq_zheng@sohu.com.
Yue LiState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China. kevinyli@um.edu.mo.

Funding

Universidade de Macau MYRG-GRG2024-00031-ICMS-UMDFZhejiang Provincial Natural Science Foundation of China D23H270001
6 · The paper itself

Abstract

Cholesterol, a key steroid in cell membranes and organelles, is vital for processes like migration and apoptosis, regulated by biosynthesis, uptake, and esterification. Its metabolism significantly impacts stem cell fate via pathways like AKT/FOXO1 and Notch, influencing proliferation, differentiation, and migration. Thus, cholesterol emerges as a promising therapeutic target. This review aims to shed light on the impact of cholesterol metabolism on stem cells and explores cholesterol-targeting drugs' potential in regenerative medicine. Our purpose is to elucidate cholesterol's role in stem cell function and guide therapeutic development.

Indexed as

CholesterolStem CellsAnimalsCell DifferentiationCell ProliferationHumansSignal TransductionCholesterolCholesterol metabolismFate determinationStem cell

Identifiers

PMID41088418
PMCPMC12523190

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.