Evidence map›Paper›PMID 41088405›Full record

ArticleCell communication and signaling : CCS2025

Activity-dependent muscarinic signalling regulates presynaptic PKC pathway and neurotransmission machinery at the neuromuscular junction.

Aleksandra Polishchuk, Laia Just-Borràs, Víctor Cilleros-Mañé, Marta Balanyà-Segura, Carolina Silvera Simón, Marta Tomàs, Meryem Jami El Hirchi, Marina Díaz-Wallach, Erica Hurtado, Josep Tomàs and 1 more

Abstract read
In one paragraph

Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aleksandra PolishchukUniversitat Rovira i Virgili, Unitat d'Histologia i Neurobiologia (UHNeurob), Facultat de Medicina i Ciències de la Salut, C/Sant Llorenç 21, 43201, Reus, Spain.ORCID http://orcid.org/0000-0001-6445-1538
Laia Just-BorràsUniversitat Rovira i Virgili, Unitat d'Histologia i Neurobiologia (UHNeurob), Facultat de Medicina i Ciències de la Salut, C/Sant Llorenç 21, 43201, Reus, Spain.ORCID http://orcid.org/0000-0003-0473-3730
Víctor Cilleros-MañéUniversitat Rovira i Virgili, Unitat d'Histologia i Neurobiologia (UHNeurob), Facultat de Medicina i Ciències de la Salut, C/Sant Llorenç 21, 43201, Reus, Spain.ORCID http://orcid.org/0000-0001-5690-9932
Marta Balanyà-SeguraUniversitat Rovira i Virgili, Unitat d'Histologia i Neurobiologia (UHNeurob), Facultat de Medicina i Ciències de la Salut, C/Sant Llorenç 21, 43201, Reus, Spain.ORCID http://orcid.org/0000-0003-0983-4944
Carolina Silvera SimónUniversitat Rovira i Virgili, Unitat d'Histologia i Neurobiologia (UHNeurob), Facultat de Medicina i Ciències de la Salut, C/Sant Llorenç 21, 43201, Reus, Spain.ORCID http://orcid.org/0000-0001-7327-8415
Marta TomàsUniversitat Rovira i Virgili, Unitat d'Histologia i Neurobiologia (UHNeurob), Facultat de Medicina i Ciències de la Salut, C/Sant Llorenç 21, 43201, Reus, Spain.ORCID http://orcid.org/0000-0002-4151-1697
Meryem Jami El HirchiUniversitat Rovira i Virgili, Unitat d'Histologia i Neurobiologia (UHNeurob), Facultat de Medicina i Ciències de la Salut, C/Sant Llorenç 21, 43201, Reus, Spain.ORCID http://orcid.org/0009-0004-5435-9622
Marina Díaz-WallachUniversitat Rovira i Virgili, Unitat d'Histologia i Neurobiologia (UHNeurob), Facultat de Medicina i Ciències de la Salut, C/Sant Llorenç 21, 43201, Reus, Spain.ORCID http://orcid.org/0009-0006-6413-9185
Erica Hurtado *Universitat Rovira i Virgili, Unitat d'Histologia i Neurobiologia (UHNeurob), Facultat de Medicina i Ciències de la Salut, C/Sant Llorenç 21, 43201, Reus, Spain.ORCID http://orcid.org/0000-0001-8930-4462
Josep Tomàs *Universitat Rovira i Virgili, Unitat d'Histologia i Neurobiologia (UHNeurob), Facultat de Medicina i Ciències de la Salut, C/Sant Llorenç 21, 43201, Reus, Spain.ORCID http://orcid.org/0000-0002-0406-0006
Maria A Lanuza *Universitat Rovira i Virgili, Unitat d'Histologia i Neurobiologia (UHNeurob), Facultat de Medicina i Ciències de la Salut, C/Sant Llorenç 21, 43201, Reus, Spain. mariaangel.lanuza@urv.cat.ORCID http://orcid.org/0000-0003-4795-4103

Funding

Agència de Gestió d'Ajuts Universitat i Recerca (AGAUR) 2021-FI-B00755Catalan Government 2021SGR01214MCIN/AEI/ 10.13039/501100011033/ by "ERDF A way of making Europe" PID2019-106332GB-I00MCIN/AEI/ 10.13039/501100011033/ by "ERDF A way of making Europe" PID2022-141252NB-I00Programa Martí i Franquès d'ajuts a la investigació. Contractes de personal investigador predoctoral en formació 2023PMF-PIPF-15Spanish Ministerio de Ciencia Innovación y Universidades PRE2020-092084
6 · The paper itself

Abstract

backgroundAcetylcholine (ACh) signalling mediated by muscarinic acetylcholine receptors (mAChRs) significantly influences various physiological functions, including muscle contraction. Among these receptors, the M

methodsTo differentiate the effects of presynaptic nerve stimulation from muscle contraction on M

resultsWe observed that presynaptic nerve stimulation resulted in a downregulation of M

conclusionOur findings reveal a detailed molecular mechanism underlying the activity-dependent interplay between M

Indexed as

Neuromuscular JunctionPresynaptic TerminalsProtein Kinase CReceptors, MuscarinicSignal TransductionSynaptic TransmissionAnimalsMaleMuscle ContractionPhrenic NerveRatsRats, Sprague-DawleyReceptor, Muscarinic M1Receptor, Muscarinic M2Protein Kinase CReceptor, Muscarinic M1Receptor, Muscarinic M2Receptors, Muscarinic

Identifiers

PMID41088405
PMCPMC12522234

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.