ArticleArthritis research & therapy2025
Multimodal brain structural and functional analysis in systemic lupus erythematosus patients without overt neuropsychiatric manifestations: associations with disease duration, organ damage, and neurocognitive function.
Article in Arthritis research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSystemic lupus erythematosus (SLE) is a chronic autoimmune disease that often affects the central nervous system (CNS), leading to structural and functional brain alterations. Although neuroimaging studies have reported significant cortical and white matter changes in SLE, findings remain inconsistent, particularly regarding disease duration and organ damage. This study aimed to comprehensively investigate multimodal brain alterations in SLE using structural and functional neuroimaging.
methodsThis cross-sectional study included 30 SLE patients without overt neuropsychiatric manifestations and 34 age-matched healthy controls (HCs). Neuroimaging data were acquired using a 3 T magnetic resonance imaging (MRI) scanner. Structural analyses included cortical and subcortical volume measurements via FreeSurfer (30 SLE, 34 HC) and white matter connectometry based on diffusion tensor imaging (DTI) using DSI Studio (29 SLE, 28 HC). Interhemispheric functional connectivity was assessed using resting-state fMRI in the CONN toolbox (27 per group). Clinical assessments included the SLEDAI-2 K, SLICC Damage Index, and SLICC Frailty Index, along with neurocognitive tests that assessed working memory, psychomotor speed, and executive function. Statistical analyses involved ANCOVA adjusted for age and intracranial volume, along with correlation analyses to explore associations between neuroimaging findings and clinical or neurocognitive measures.
resultsSLE patients exhibited significantly reduced volumes in the right occipital lobe (F = 11.274, η
conclusionsEven in the absence of overt neuropsychiatric symptoms, SLE patients demonstrated structural brain changes-specifically reduced occipital and thalamic volumes and widespread white matter disruptions-associated with disease duration, organ damage, and neurocognitive dysfunction. Functional interhemispheric connectivity was globally preserved but impaired in the moderate activity subgroup.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.