Evidence map›Paper›PMID 41088290›Full record

SynthesisAnnals of clinical microbiology and antimicrobials2025

Resistance profile and influence factors of carbapenem-resistant Klebsiella pneumoniae (CRKP) causing infections in China: a systematic review and meta-analysis.

Xiaolu Yang, Zhenghao Lou, Xinrui Wang, Zhen Li, Qiyu Liu, Kexin Guo, Yu Yang, Lu Gong, Kun Wang, Hao Xu and 5 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Annals of clinical microbiology and antimicrobials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Multicenter Surveillance ofInfection and drug resistance · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiaolu Yang *Zhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang, China.
Zhenghao Lou *Zhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang, China.
Xinrui WangCollege of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Zhen LiDepartment of Pathology, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, NO. 311 Yingpan Road, Kaifu District, Changsha, 410005, Hunan, China.
Qiyu LiuZhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang, China.
Kexin GuoZhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang, China.
Yu YangZhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang, China.
Lu GongZhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang, China.
Kun WangZhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang, China.
Hao XuCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Beiwen ZhengCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Wenhong LiuZhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang, China.
Chuanxi FuZhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang, China.
Hui Chen *Department of Pathology, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, NO. 311 Yingpan Road, Kaifu District, Changsha, 410005, Hunan, China. 379030550@qq.com.
Xiawei Jiang *Zhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang, China. xiaweijiang@zcmu.edu.cn.

Funding

Fundamental Research Funds for the Central Universities 2022ZFJH003National Key Research and Development Program of China 2020YFE0204300National Natural Science Foundation of China 82072314Shandong Provincial Laboratory Project SYS202202
6 · The paper itself

Abstract

The prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections has surged in China over the past decade, posing a significant public health concern. However, comprehensive data on CRKP antimicrobial resistance patterns and the impact of the COVID-19 pandemic on these patterns in China remain unclear. We conducted a systematic review of CRKP infections in China, utilizing data from PubMed spanning 2006 to July 2023. We focused on resistance rates of CRKP causing infections, examining variations across time, regions, and age groups, as well as factors contributing to antimicrobial resistance. Our analysis included 68 studies from 19 provinces in China, comprising 1,284 CRKP isolates obtained from 779 patients. The overall mortality rate for CRKP infections in China was 27% (95% CI: 0.14-0.41, I

Indexed as

Anti-Bacterial AgentsCarbapenem-Resistant EnterobacteriaceaeCarbapenemsKlebsiella InfectionsKlebsiella pneumoniaeChinaCOVID-19Drug Resistance, BacterialDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsSARS-CoV-2Anti-Bacterial AgentsCarbapenemsAntimicrobial resistanceCarbapenem-resistantChinaKlebsiella pneumoniae

Identifiers

PMID41088290
PMCPMC12519821

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.