ArticleWorld journal of surgical oncology2025
miR-1287-5p suppresses proliferation, migration, invasion and promotes apoptosis in gastric cancer cells through targeting LAMTOR3.
Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- METTL3-dependent mJournal of translational medicine · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveThis research attempts to clarify the function of miR-1287-5p in gastric cancer (GC) and the mechanisms that underlie it.
methodsMiR-1287-5p and LAMTOR3 mRNA levels were determined using qRT-PCR.Western blot analysis was used to identify LAMTOR3 protein expression.The GC cells were assessed for proliferation, migration, invasion, and apoptosis using the CCK-8, wound-healing, transwell invasion assay, and flow cytometry tests, respectively.The dual-luciferase reporter assay was used to validate the miR-1287-5p target.
resultsGC had lower miR-1287-5p levels than normal cells or tissues.MiR-1287-5p over-expression dramatically reduced GC cell proliferation, migration, invasion, and accelerated apoptosis in contrast to the impact of miR-1287-5p knockdown.The dual-luciferase reporter experiment confirmed the direct targeting relationship between miR-1287-5p and LAMTOR3.Rescue experiments showed that GC cells proliferation, migration, invasion, and apoptosis caused by miR-1287-5p were all reversed by concurrent over-expression or down-regulation of LAMTOR3.
conclusionsThis current study found that miR-1287-5p suppressed GC cells proliferation, migration, and invasion while increasing apoptosis by decreasing LAMTOR3 expression. This revealed that miR-1287-5p may function as a plausible therapeutic target or biomarker for GC.
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