SynthesisBMC oral health2025
Meta-analysis of randomized controlled trials: efficacy of vitamin C mesotherapy for gingival hyperpigmentation in adults.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clinical characteristics and factors associated with dentition defects in patients with diabetes mellitus and concomitant endodontic disease.American journal of translational research · 2026Article
- Clinical and patient-reported outcomes of microneedling with ascorbic acid versus scalpel technique for gingival depigmentation: A randomized clinical trial.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGingival hyperpigmentation is a common aesthetic concern, necessitating evidence-based evaluation of depigmentation treatments, particularly vitamin C mesotherapy.
methodsA systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted across PubMed, EMBASE, and Web of Science databases. Data were extracted and analyzed using both random and common effects models to calculate mean difference (MD) and 95% confidence interval (CI). Heterogeneity was assessed using I², tau², and Q statistics.
resultsThe meta-analysis, including 11 RCTs with a total of 236 participants, revealed significant effects of vitamin C mesotherapy. For Visual Analog Scale (VAS) scores, the MD was 2.0580 [1.6161; 2.4998] (p < 0.0001), with high heterogeneity (I² = 90.6%). The overall effect for GPI scores was not statistically significant (MD = -0.72, 95% CI [-1.47, 0.03], p = 0.0585), with high heterogeneity (I
conclusionVitamin C mesotherapy demonstrates significant efficacy in reducing gingival hyperpigmentation, notably showing a favorable outcome compared to diode laser for DOPI scores and no significant difference from topical gel. While laser and surgical interventions generally present larger overall mean differences, vitamin C mesotherapy remains a valuable treatment modality, adding to the diverse effective options for managing gingival hyperpigmentation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.