ReviewParasites & vectors2025
Pyrethroid resistance in Aedes aegypti: genetic mechanisms worldwide, and recommendations for effective vector control.
Review in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Insecticide resistance in larval populations of Aedes aegypti and Aedes albopictus from Panama.Tropical medicine and health · 2026Article
- Small molecules as arthropod kinin receptor antagonists, feeding modulators, or novel mosquitocidal agents.Pest management science · 2026Article
- Developmental Consequences of Early-Life Exposure and Adulticidal Effects ofMolecules (Basel, Switzerland) · 2026Article
- Review
- Rising of pyrethroid resistance mutations (kdr) in the dengue vectorFrontiers in public health · 2026Article
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Authors and funding
2 authors.
Funding
Abstract
backgroundThe Aedes aegypti mosquito, a primary vector of arboviruses such as dengue, Zika, yellow fever, and chikungunya, poses a significant public health threat worldwide. Its adaptability and genetic diversity complicate control efforts, enabling rapid resistance evolution. Pyrethroid insecticides, a cornerstone of vector control, target voltage-gated sodium channels, yet resistance driven by knockdown resistance (kdr) mutations and detoxification mechanisms have undermined their efficacy.
methodsThis review summarizes findings from a targeted literature search, exploring the genetic and molecular mechanisms driving pyrethroid resistance worldwide, focusing on kdr mutations.
resultsOver twenty distinct kdr alleles were reported across global populations, including those functionally confirmed on the recombinant sodium channel such as V253F, V410L, L982W, I1011M, V1016G and F1534C. Indicators of the global impact of pyrethroid resistance include the field selection of highly resistant populations in which kdr mutation frequencies exceed 90%, deltamethrin resistance ratios as high as 249-fold, and permethrin resistance exceeding 500-fold. In laboratory-selected pyrethroid-resistant strains, resistance ratios can surpass 1,000-fold.
conclusionsWe provide an updated status of pyrethroid resistance in Ae. aegypti and a framework on how the results of molecular tests and toxicity bioassays can be applied to practical mosquito control programs. Control strategies must integrate multidisciplinary approaches, including Integrated Vector Management (IVM), which emphasizes targeted interventions, community engagement, and sustainable practices. Despite advances in analyzing resistance, very few studies measure frequency of genotypes, determine phenotypic resistance (resistance ratios), and assess standardized field efficacy in the same populations, including field measurements of pesticide deposited, leaving a critical implementation gap. This lack of integration creates major gaps in translating laboratory resistance diagnostics into actionable field control decisions. Empirical data on how cuticular thickening and behavioral avoidance alter post-treatment survivorship are especially sparse, limiting the predictive power of current methodologies. By assessing the current understanding of pyrethroid resistance in Ae. aegypti, this review informs the development of resilient, evidence-based interventions to mitigate the public health impact of diseases transmitted by Ae. aegypti.
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