Evidence map›Paper›PMID 41088137›Full record

ReviewJournal of ovarian research2025

Recent advances in reprogramming lactate metabolism in polycystic ovary syndrome.

Jing Xu, Wei-Hong Chen, Ming-Na Huang, Ling-Tao Zheng, Si-Yan Huang, Shu Lin, Qi-Rong Shi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing Xu *Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, No.34 North Zhongshan Road, Quanzhou, 362000, Fujian Province, China.
Wei-Hong Chen *Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, No.34 North Zhongshan Road, Quanzhou, 362000, Fujian Province, China.
Ming-Na HuangDepartment of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, No.34 North Zhongshan Road, Quanzhou, 362000, Fujian Province, China.
Ling-Tao ZhengDepartment of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, No.34 North Zhongshan Road, Quanzhou, 362000, Fujian Province, China.
Si-Yan HuangDepartment of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, No.34 North Zhongshan Road, Quanzhou, 362000, Fujian Province, China.
Shu LinCentre of Neurological and Metabolic Research, the Second Affiliated Hospital of Fujian Medical University, No.34 North Zhongshan Road, Quanzhou, 362000, Fujian Province, China. shulin1956@126.com.
Qi-Rong ShiDepartment of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, No.34 North Zhongshan Road, Quanzhou, 362000, Fujian Province, China. wsqy214@163.com.

Funding

the General Project of Qihang Fund of Fujian Medical University 2024QH1120the Science and Technology Project of Quan Zhou 2025QZNG009
6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is a prevalent and complex endocrine disorder affecting 4–20% of women of reproductive age worldwide. It is characterized by dyslipidemia, insulin resistance, weight gain, and increased risk of cardiovascular disease. An imbalance in the hypothalamic-pituitary-ovarian axis is an important pathophysiological basis of PCOS. Lactate, a glycolytic product and an important energy source, also regulates gene transcription through histone lactylation, a novel post-translational modification. Emerging evidence highlights the crucial role of lactate and lactylation in cancer, inflammation, and metabolic reprogramming, although the exact mechanisms remain unclear. Based on the manifestations of PCOS, we hypothesized a potential link between lactate levels, lactylation, and PCOS. This review explores the role of lactate in PCOS pathophysiology, examines the regulatory effect of metabolic reprogramming on various pathophysiological scenarios, and discusses the therapeutic potential of targeting lactate metabolism in PCOS management.

Indexed as

Lactic AcidPolycystic Ovary SyndromeAnimalsFemaleHumansInsulin ResistanceMetabolic ReprogrammingLactic AcidInflammationInsulin resistanceLactate metabolismMetabolic reprogrammingPCOS

Identifiers

PMID41088137
PMCPMC12522418

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.