Evidence map›Paper›PMID 41088135›Full record

ArticleJournal of translational medicine2025

Maternal monocyte-derived IFN-α1 triggers early fetal demise.

Dandan Wang, Wu Li, Kai Jiang, Yue Xu, Ruhua Deng, Xingbo Yang, Huici Jiang, Jiayi Liang, Ke Wei, Jinlong Qin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dandan WangShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Shanghai Fourth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Wu LiDepartment of Gynaecology and Obstetrics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Kai JiangShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Shanghai Fourth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Yue XuShanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Ruhua DengShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Shanghai Fourth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Xingbo YangShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Shanghai Fourth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Huici JiangDepartment of Gynaecology and Obstetrics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiayi LiangDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Ke WeiShanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Jinlong QinDepartment of Gynaecology and Obstetrics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yaozu XiangShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Shanghai Fourth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China. yaozu.xiang@tongji.edu.cn.ORCID 0000-0002-1452-6455

Funding

the National Natural Science Foundation of China 82270350
6 · The paper itself

Abstract

backgroundEarly fetal demise (EFD), defined as the absence of cardiac activity in a visible fetus, represents a severe form of pregnancy loss with incompletely understood mechanisms. While genetic factors constitute the primary etiology, emerging evidence implicates maternal immune dysregulation in EFD pathogenesis, though the specific cellular and molecular pathways remain undefined. MATERIALS AND

methodsWe performed single-cell RNA sequencing (scRNA-seq) on peripheral blood mononuclear cells (PBMCs) from a 20-subject cohort comprising EFD patients, healthy pregnant women, and non-pregnant controls. Parallel murine studies involved GFP-labeled monocyte transfer into E8.5 pregnant mice, with subsequent embryonic viability assessment. Human villous tissues from EFD and control pregnancies were analyzed alongside functional characterization using primary neonatal rat cardiomyocytes exposed to IFN-α1.

resultsScRNA-seq revealed significant CD14+ monocyte accumulation in EFD patients versus controls. In murine models, adoptively transferred maternal monocytes breached the placental barrier, inducing 25.7% embryonic lethality. EFD villous tissues exhibited CD14+ monocyte infiltration with selective IFN-α1 elevation (absent in IFN-α2). Cardiomyocyte functional assays demonstrated IFN-α1-mediated contractile impairment through significant reduction in beating frequency.

conclusionThese findings establish maternal CD14+ monocytes as key mediators of EFD via IFN-α1-dependent cardiac dysfunction, revealing a targetable immune axis for pregnancy preservation. The study provides the first direct evidence linking monocyte trafficking with embryonic viability, offering new therapeutic paradigms for miscarriage prevention.

Indexed as

Fetal DeathInterferon-alphaMonocytesAdultAnimalsFemaleHumansLipopolysaccharide ReceptorsMyocytes, CardiacPregnancyInterferon-alphaLipopolysaccharide ReceptorsCD14+ monocytesEarly fetal demiseIFN-α1

Identifiers

PMID41088135
PMCPMC12523047

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.