Evidence map›Paper›PMID 41088133›Full record

ArticleMolecular brain2025

BDNF genotype associated with changes in cortical thickness, severity of symptoms, and cognitive impairments in mild traumatic brain injury.

Lei Shi, Yizhen Pan, Jie Yuan, Jue Zhang, Zhiqi Lee, Xuan Li, Haonan Zhang, Xiang Zhang, Tingting Wu, Jierui Ding and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Lei Shi *The Key Laboratory of Biomedical Information Engineering, Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education, Xi'an Jiaotong University, Xi'an, 712000, China.
Yizhen Pan *The Key Laboratory of Biomedical Information Engineering, Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education, Xi'an Jiaotong University, Xi'an, 712000, China.
Jie Yuan *Departments of Radiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Jue ZhangDepartment of Neurosurgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Zhiqi LeeThe Key Laboratory of Biomedical Information Engineering, Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education, Xi'an Jiaotong University, Xi'an, 712000, China.
Xuan LiThe Key Laboratory of Biomedical Information Engineering, Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education, Xi'an Jiaotong University, Xi'an, 712000, China.
Haonan ZhangThe Key Laboratory of Biomedical Information Engineering, Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education, Xi'an Jiaotong University, Xi'an, 712000, China.
Xiang ZhangThe Key Laboratory of Biomedical Information Engineering, Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education, Xi'an Jiaotong University, Xi'an, 712000, China.
Tingting WuThe Key Laboratory of Biomedical Information Engineering, Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education, Xi'an Jiaotong University, Xi'an, 712000, China.
Jierui DingThe Key Laboratory of Biomedical Information Engineering, Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education, Xi'an Jiaotong University, Xi'an, 712000, China.
Tao LiuThe Key Laboratory of Biomedical Information Engineering, Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education, Xi'an Jiaotong University, Xi'an, 712000, China.
Nengrui GuoThe Key Laboratory of Biomedical Information Engineering, Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education, Xi'an Jiaotong University, Xi'an, 712000, China.
Zhuonan WangPET-CT Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. wangzhuonan424@163.com.
Lijun BaiThe Key Laboratory of Biomedical Information Engineering, Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education, Xi'an Jiaotong University, Xi'an, 712000, China. bailijun@xjtu.edu.cn.

Funding

funds for Natural Science Basic Research Program of Shaanxi 2022JC-55National Key Research and Development Program of China 2023YFC3503600National Natural Science Foundation of China NSFC82071993
6 · The paper itself

Abstract

objectiveBrain-derived neurotrophic factor (BDNF) is a critical blood protein for brain function; however, its genotypic influence on clinical outcomes and brain structure following mild traumatic brain injury (mTBI) remains unclear. This study investigated the relationship between BDNF polymorphisms and cognitive impairment, symptom severity, and cortical structural injury in mTBI patients. MATERIALS AND

methodsSixty-one mTBI patients underwent neuropsychological assessments and MRI scans within one week post-injury, with 46 patients followed up at one month. Fifty-two healthy controls were included for comparison. Patients with mTBI exhibited clinical symptoms, cognitive impairment, and alterations in cortical thickness during in the acute phase.

resultsBDNF Met gene carriers (n = 41) and Val gene carriers (n = 20) demonstrated different cognitive performance in the acute phase and exhibited distinct recovery trajectories. Val carriers showed significantly better cognitive flexibility compared to Met carriers (p = 0.028) during the acute phase and greater improvement in clinical symptoms at one month (p = 0.035). Follow-up MRI scans revealed more extensive and statistically significant alterations in cortical thickness in Met carriers than in Val carriers (p < 0.01), particularly in regions associated with cognitive and emotional regulation.

conclusionThese findings suggest that BDNF polymorphisms in mTBI patients are associated with brain structural changes and may serve as valuable biomarkers for identifying individuals at risk for long-term clinical symptoms and cognitive impairment.

Indexed as

Brain ConcussionBrain Cortical ThicknessBrain-Derived Neurotrophic FactorCerebral CortexCognitive DysfunctionGenetic Association StudiesAdultCase-Control StudiesFemaleGenotypeHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPolymorphism, Single NucleotideBDNF protein, humanBrain-Derived Neurotrophic FactorBrain-Derived neurotrophic factorClinical symptomsCognitive impairmentCortical thicknessMild traumatic brain injury

Identifiers

PMID41088133
PMCPMC12522302

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.