SynthesisBMC cancer2025
The significant prognostic value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score in digestive system cancers: a systematic review and meta-analysis.
Synthesis in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between the HALP score and survival of patients with esophageal or gastro-esophageal junction cancer: a meta-analysis.Frontiers in oncology · 2026Pooled it
- Early Childhood Caries and Immunonutritional Status in Preschool Children: A Retrospective Comparative Study of the HALP Score and Hematological Biomarkers.Journal of clinical medicine · 2026Article
- Prognostic value of the HALP score in patients undergoing emergency surgery for gastroduodenal perforation.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Emergency department evaluation of immature granulocytes for complicated acute appendicitis: a retrospective cohort study.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Prognostic role of hemoglobin, albumin, lymphocyte and platelet score in esophageal cancer: a systematic review and meta-analysis.Journal of thoracic disease · 2026Article
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- Machine learning-based prognostic model integrating preoperative HALP score and lactate dehydrogenase for predicting postoperative recurrence of prostate cancer.World journal of surgical oncology · 2026Article
- Early Neurological Improvement and Ambulation Recovery After Delayed Surgery in Surgically Selected Nonambulatory Metastatic Epidural Spinal Cord Compression: A Retrospective Cohort Study.Current oncology (Toronto, Ont.) · 2026Article
- Prognostic Value of HALP Score for In-Hospital Mortality in Patients with Infective Endocarditis.Journal of clinical medicine · 2026Article
- HALP outperforms systemic inflammatory biomarkers for prognosis in locally advanced cervical cancer treated with concurrent chemoradiotherapy.Biomolecules & biomedicine · 2026Article
- Second-Trimester Fibrinogen-to-Albumin Ratio and Platelet Activation Markers Compared with the HALP Score for Predicting Preeclampsia.Diagnostics (Basel, Switzerland) · 2026Article
- HALP score outperforms systemic inflammatory biomarkers for prognosis in locally advanced rectal cancer.Biomolecules & biomedicine · 2026Observational
- Thrombocytosis in cancer patients: when more is not better-in fact, the opposite.Cancer metastasis reviews · 2026Review
- The preoperative hemoglobin, albumin, lymphocyte, and platelet score as a prognostic Indicator for survival in gastric and colorectal cancer patients.Frontiers in nutrition · 2026Article
- The predictive value of malnutrition on the prognosis of severe respiratory failure in elderly patients: a multicenter retrospective study based on interpretable machine learning.Frontiers in nutrition · 2026Article
- A clinical study of the CALLY index and HALP score for evaluating response to FOLFOX in colorectal cancer with lung metastases.American journal of translational research · 2026Article
- An Evaluation of the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) Score in Cushing's Syndrome and Mild Autonomous Cortisol Secretion.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDigestive system cancers are a major global health burden, necessitating reliable and cost-effective prognostic biomarkers for clinical decision-making. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, an integrated immune-nutrition marker, has emerged as a potential prognostic tool in various malignancies. This meta-analysis evaluated the prognostic value of the HALP score in patients with digestive system cancers.
methodsA systematic search was performed in PubMed, PMC, and Web of Science database for studies assessing HALP scores calculated from pre-treatment blood tests and reporting survival outcomes in patients with digestive system cancers. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled to evaluate the prognostic significance of the HALP score.
resultsA total of 30 articles comprising 34 studies and 9,389 patients were included. High HALP scores were significantly associated with improved survival outcomes. The pooled HR for overall survival (OS) was 1.762 (95% CI: 1.570-1.977, P < 0.001), and similar results were found for disease-free survival (DFS) (HR = 1.841, 95% CI: 1.311-2.585, P < 0.001), recurrence-free survival (RFS) (HR = 1.583, 95% CI: 1.374-1.824, P < 0.001), cancer-specific survival (CSS) (HR = 1.930, 95% CI: 1.590-2.341, P < 0.001), and progression-free survival (PFS) (HR = 1.444, 95% CI: 1.068-1.954, P = 0.017). Subgroup analyses confirmed the robustness of these findings across different treatment strategies and cancer types. Sensitivity and bias analyses (P = 0.103) supported the reliability of these results.
conclusionThe HALP score is a promising prognostic biomarker for digestive system cancers, offering potential for clinical application in personalizing treatment strategies. Future studies should aim to standardize methodologies and validate HALP in prospective multicenter trials.
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