ArticleBMC oral health2025
Protective and therapeutic effects of hexagonal boron nitride against hydrogen peroxide-induced oxidative damage in human gingival fibroblasts.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
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7 authors.
Funding
Abstract
backgroundOxidative stress plays a significant role in the progression of periodontal diseases. Hexagonal boron nitride (hBN) nanoparticles have antimicrobial, antiplaque, and antioxidant properties. The aim of this study to evaluate the protective and therapeutic effects of hBN against oxidative stress induced by hydrogen peroxide (H
methodsIn this study, a primary cell line of HGFs was used. Oxidative stress was induced by treating the cells with 800 µM H
resultshBN did not negatively affect cell viability in HGF cells at any concentration. The application of hBN to HGF cells before and after oxidative damage resulted in statistically significant (P < 0.001), albeit modest improvements in cell viability (2-5.5% and 3-6.5%, respectively). No significant differences were observed in TOS (P = 0.234), indicating that the cytoprotective effects were not mediated via alterations in TOS.
conclusionsWithin the limitations of this in vitro study, hBN was found to enhance cell viability under H₂O₂-induced oxidative stress in HGF cells. These findings suggest a potential role for hBN in modulating antioxidant responses and supporting periodontal healing processes. However, their clinical relevance remains uncertain. Therefore, further mechanistic studies and clinical investigations are required to validate the potential adjunctive role of hBN in the prevention and treatment of periodontal diseases.
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