ArticleBMC cancer2025
Myosteatosis is associated with advanced TNM stage and tumor features in young females with breast cancer.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- PET/CT-derived whole-body composition and survival in resectable NSCLC: double machine learning-based adjusted association analysis of intermuscular adiposity burden and sex-specific metabolic phenotypes.European journal of nuclear medicine and molecular imaging · 2026Article
- Prognostic value of body composition analysis in cancer patients treated with immunotherapy: a systematic evaluation of TotalSegmentator-based biomarkers.La Radiologia medica · 2026Article
- Prognostic role of myosteatosis in predicting MACE and mortality after TAVR: insights from CT-based body composition analysis.The journal of nutrition, health & aging · 2026Article
- Baseline Body Composition Characteristics and Overall Survival in Young Women with Breast Cancer: Matched Case-Control Study Nested Within a Cohort.Tomography (Ann Arbor, Mich.) · 2026Article
- Artificial intelligence standardizes CT-based body composition analysis in breast cacer to address methodological heterogeneity.Frontiers in oncology · 2026Review
- Visceral and Subcutaneous Fat Deposits Exhibit Distinct Roles in the Initiation and Progression of Breast Cancer.Breast cancer (Dove Medical Press) · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to explore the associations between body composition and markers related to disease severity in young females newly diagnosed with breast cancer.
methodsThis cross-sectional study was conducted across two Oncology units. Inclusion criteria were females aged 20 to 40 years, newly diagnosed with ductal invasive breast cancer (stages I to IV), who had undergone abdominal computed tomography (CT) scans. CT images at the third lumbar vertebra (L3) level were used to assess body composition, including the cross-sectional area of skeletal muscle (cm²), skeletal muscle radiodensity (SMD, HU), intermuscular adipose tissue (IMAT, cm²), and total adipose tissue with its visceral and subcutaneous compartments.
resultsA total of 190 females were included in this analysis (median age: 35 years, quartile range: 31 to 37). 69.5% were diagnosed at stages III to IV. Patients at stages III to IV exhibited a significantly higher frequency of myosteatosis, assessed by high IMAT (P = 0.003). A higher IMAT was independently associated with higher odds of presenting with stages III to IV (OR
conclusionOur findings demonstrate the potential significance of evaluating myosteatosis in young females newly diagnosed with breast cancer. The infiltration of adipose tissue and fat within skeletal muscle (i.e., myosteatosis) may hold implications for understanding disease severity, even when overall muscle mass quantity remain unchanged.
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