ArticleBMC infectious diseases2025
Nonlinear relationship between BMI and 30-day in-hospital mortality in ICU sepsis patients: a multicenter retrospective cohort study.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundWhile obesity paradox has been observed in various critical conditions, its role in sepsis remains unclear. This study aimed to investigate the relationship between body mass index (BMI) and 30-day in-hospital mortality among intensive care unit (ICU) patients with sepsis.
methodsThis retrospective study analyzed data from 17,510 adult sepsis patients (aged ≥ 18 years) with ICU stays between 24 h and 30 days, complete mortality data, and available BMI measurements, using the eICU Collaborative Research Database (eICU-CRD v2.0) collected in the United States between 2014 and 2015. BMI was the exposure variable, and 30-day in-hospital mortality was the outcome. Covariates included demographics, clinical parameters, comorbidities, and treatments. Univariate and multivariate logistic regression models examined the association between BMI and mortality, while generalized additive models with smooth curve fitting explored potential nonlinear relationships.
resultsThe median BMI among the 17,510 patients was 28.91 kg/m². The overall 30-day in-hospital mortality was 16.7% (95% CI: 16.2%–17.3%). A non-linear relationship between BMI and mortality was identified with an inflection point at 21.5 kg/m². Below this point, each unit increase in BMI was associated with a 9% decrease in mortality risk (OR: 0.91, 95% CI: 0.87–0.94, p < 0.001). Above this point, the association became insignificant (OR: 0.99, 95% CI: 0.99-1.00, p = 0.054).
conclusionIn ICU patients with sepsis, BMI is nonlinearly associated with 30-day in-hospital mortality, showing a significant negative correlation when BMI is ≤ 21.5 kg/m². These findings provide valuable insights for clinical risk assessment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.