Evidence map›Paper›PMID 41087978›Full record

ArticleBMC cancer2025

SOX4 enhances tumor progression and cisplatin resistance in orthotopic mouse xenograft model of head and neck squamous cell carcinoma.

Hye-Bin Jang, Sun-Ae Kim, Eun Kyung Jung, Kyung-Hwa Lee, Joon Kyoo Lee, Young-Eun Joo, Yong Yeon Jeong, Sang Chul Lim, Tae Mi Yoon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hye-Bin JangDepartments of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea.
Sun-Ae KimDepartments of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea.
Eun Kyung JungDepartments of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea.
Kyung-Hwa LeeDepartment of Pathology, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea.
Joon Kyoo LeeDepartments of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea.
Young-Eun JooDepartment of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea.
Yong Yeon JeongDepartment of Radiology, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea.
Sang Chul LimDepartments of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea.
Tae Mi YoonDepartments of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea. lovetaem96@gmail.com.

Funding

National Research Foundation of Korea 2020R1F1A1076054
6 · The paper itself

Abstract

backgroundSRY-related high-mobility-group box gene 4 (SOX4) is overexpressed in various cancers and has been studied as a therapeutic target in multiple malignancies. Therefore, this study aims to investigate the role of SOX4 in cancer progression and chemoradioresistance in head and neck squamous cell carcinoma (HNSCC).

methodsUtilizing in vitro silencing techniques and an orthotopic mouse xenograft model that simulates HNSCC biological characteristics, the effect of SOX4 modulation on cell proliferation, invasion, migration, and apoptosis was assessed.

resultsThe results showed that SOX4 knockdown led to significant inhibition of cell proliferation, reduced invasion and migration capabilities, and increased apoptosis in human HNSCC cells. Furthermore, SOX4 knockdown enhanced chemoradiosensitivity, as evidenced by increased apoptosis levels following treatment with cisplatin and irradiation. Conversely, SOX4 overexpression in an orthotopic mouse model of HNSCC significantly promotes tumor invasion, metastasis, and chemoresistance to cisplatin.

conclusionsThese findings highlight the essential role of SOX4 in HNSCC progression and treatment resistance, suggesting SOX4 is a predictive biomarker and potential therapeutic target for improving treatment outcomes in patients with HNSCC.

Indexed as

CisplatinDrug Resistance, NeoplasmHead and Neck NeoplasmsSOXC Transcription FactorsSquamous Cell Carcinoma of Head and NeckAnimalsAntineoplastic AgentsApoptosisCell Line, TumorCell MovementCell ProliferationDisease Models, AnimalDisease ProgressionGene Expression Regulation, NeoplasticHumansMiceAntineoplastic AgentsCisplatinSOX4 protein, humanSOXC Transcription FactorsApoptosisChemoresistanceHead and neck squamous cell carcinomaMolecular targeted therapyRadioresistanceSOX4 protein

Identifiers

PMID41087978
PMCPMC12522388

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.