Evidence map›Paper›PMID 41087973›Full record

ArticleBMC cardiovascular disorders2025

Pulmonary arterial compliance as a long-term prognostic indicator in pulmonary arterial hypertension associated with adult congenital heart disease: results from a National multicenter prospective registry.

Qimou Li, Hongrui Yu, Changming Xiong, Qing Gu, Zaixin Yu, Yuhao Liu, Weifeng Wu, Xianyang Zhu, Huijun Han, Jianguo He

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01417338 (National, Prospective, Multicenter,Observational Registry Study on Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension in China), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01417338 unknown statusnot on this map

National, Prospective, Multicenter,Observational Registry Study on Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension in China

TypeobservationalSponsorChinese Academy of Medical Sciences, Fuwai HospitalRan2009 to 2020Enrolled3,079ConditionsPulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Death
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qimou Li *Department of Pulmonary Vascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing, 100037, China.
Hongrui Yu *Department of Pulmonary Vascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing, 100037, China.
Changming XiongDepartment of Pulmonary Vascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing, 100037, China.
Qing GuEmergency Center, National Center for Cardiovascular Diseases, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Zaixin YuDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yuhao LiuHeart Centre of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 450003, P.R. China.
Weifeng WuDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Xianyang ZhuDepartment of Congenital Heart Disease, General Hospital of Northern Theater Command, Shenyang, 210100, P.R. China.
Huijun HanDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, School of Basic Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.
Jianguo HeDepartment of Pulmonary Vascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing, 100037, China. hejianguofw@163.com.

Funding

China Key Research Projects of the 11th National Five-Year Development Plan 2006BAI01A07China Key Research Projects of the 12th National Five-Year Development Plan No. 2011BAI11B15National Key Research and Development Program of China No. 2016YFC1304400
6 · The paper itself

Abstract

backgroundPulmonary arterial compliance (PAC) reflects the pulsatile load and predicts outcome in pulmonary arterial hypertension (PAH). The prognostic role of PAC in the heterogeneous patient population of PAH associated with congenital heart disease (PAH-CHD) is poorly defined. This study aimed to explore the prognostic value of PAC in patients with PAH-CHD.

methodsAdult patients diagnosed with PAH-CHD were collected from a PAH multicenter prospective registry between August 2009 and December 2019. The primary endpoint was all-cause mortality. Multivariable Cox regression and restricted cubic spline (RCS) analysis were used to evaluate the association between PAC and the primary endpoint. Subgroup and interaction analysis between PAC and shunts or defect characteristics were explored. Incremental predictive performance was evaluated by calculating the C-index, continuous net reclassification improvement, and integrated discrimination improvement.

resultsA total of 434 adult PAH-CHD patients were enrolled. The median follow-up time was 52.2 months. The survival rate of patients in the lower PAC group was significantly worse than those in the higher PAC group (Log-rank P < 0.001). Multivariable Cox regression analysis showed that PAC independently predicted all-cause mortality after adjustment for other prognostic factors, whether as a continuous variable (HR = 0.665, 95%CI 0.503-0.878, P = 0.004) or a dichotomous variable (HR = 0.251, 95%CI 0.124-0.507, P < 0.001). A linear relationship between PAC and all-cause mortality was identified by RCS analysis. Subgroup analysis revealed that the impact of PAC might be affected by the presence of post-tricuspid shunt. Incorporating PAC into the validated risk models significantly improved the reclassification and discrimination ability for all-cause mortality.

conclusionPAC was significantly associated with all-cause mortality in patients with PAH-CHD and provided additional value on risk assessment. The role of PAC may vary across different clinical subgroups.

trial registrationClinicalTrials.gov (NCT01417338), registered 16th August 2011.

Indexed as

Arterial PressureHeart Defects, CongenitalPulmonary Arterial HypertensionPulmonary ArteryVascular StiffnessAdultCause of DeathFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRegistriesRisk AssessmentCongenital heart diseaseEisenmenger syndromePrognosisPulmonary arterial compliancePulmonary arterial hypertensionRight heart catheterizationRisk stratification

Identifiers

PMID41087973
PMCPMC12522511

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.