Evidence map›Paper›PMID 41087940›Full record

ReviewBMC neurology2025

Clinical characteristics and prognostic indicators in Listeria monocytogenes meningoencephalitis: A retrospective case series and literature review.

Chong Li, Mengmeng Liu, Ying Ji, Shushu Pang, Jin Tian, Xiaowen Li, Meng Zhang, Yaqin Gu, Hao Chen, Lin He and 1 more

Abstract readReview
In one paragraph

Review in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. A Case ofInfection and drug resistance · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chong Li *Graduate School, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Mengmeng Liu *Department of General Practice, The Inner Mongolia People's Hospital, Huhhot, 010017, Inner Mongolia, China.
Ying Ji *Graduate School, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Shushu PangDepartment of Neurology, Xuzhou Medical University Affiliated Hospital, Xuzhou, 221600, Jiangsu, China.
Jin TianGraduate School, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Xiaowen LiGraduate School, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Meng ZhangDepartment of General Practice, The Inner Mongolia People's Hospital, Huhhot, 010017, Inner Mongolia, China.
Yaqin GuDepartment of Neurology, Beijing Xuanwu Hospital, Beijing, 100053, China.
Hao ChenDepartment of Neurology, Xuzhou Medical University Affiliated Hospital, Xuzhou, 221600, Jiangsu, China.
Lin HeDepartment of Neurology, Xuzhou Medical University Affiliated Hospital, Xuzhou, 221600, Jiangsu, China. 332603099@qq.com.
Yihan WuDepartment of General Practice, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, 100050, China. mon_wyhan@163.com.

Funding

Inner Mongolia Academy of Medical Sciences Scientific Research Joint Fund key Project 2023GLLH0034Inner Mongolia Medical University Joint Project YKD2022LH060Inner Mongolia Region Health Science and Technology Plan Project 202202019The opening project of key laboratories of colleges and universities in Jiangsu Province in 2020 XZSYSKF2020010The project of Xuzhou Science and Technology Bureau in 2023 KC23262The Youth Medical Science and Technology Innovation Project of Xuzhou Municipal Health Commission in 2020 XWKYHT20200001
6 · The paper itself

Abstract

backgroundListeria monocytogenes meningoencephalitis (LMM) is a rare but severe central nervous system (CNS) infection. This study aimed to characterize the clinical manifestations, diagnostic findings, treatment responses, and prognostic factors associated with LMM.

methodsWe retrospectively analyzed the clinical data of 13 patients diagnosed with LMM at Xuzhou Medical University Affiliated Hospital between 2018 and 2023. An additional five cases were identified through a literature search in the China National Knowledge Infrastructure (CNKI) and Wanfang databases from 2019 to 2022. Clinical features, cerebrospinal fluid (CSF) and blood test results, imaging findings, treatments, and outcomes were summarized.

resultsAmong 18 patients (11 males, 7 females; mean age 51.6 ± 17.2 years), all had acute onset with fever (100%), headache (83.3%), and altered consciousness (77.8%). CSF analysis showed elevated pressure in 83.3%, increased leukocytes and protein in all cases, and variable glucose levels. LM was cultured from CSF in 10 patients and detected via metagenomic next-generation sequencing (mNGS) in 12. Imaging findings included hydrocephalus in 4 cases and meningeal enhancement in 2 cases. Full recovery was observed in 2 cases, improvement in 9, palliative care in 3, and death in 4. Early seizures and hydrocephalus were linked to worse outcomes.

conclusionListeria monocytogenes meningoencephalitis is a rapidly progressive CNS infection with variable presentations and significant risk of poor outcomes. Early recognition, appropriate antimicrobial coverage, and timely diagnostic testing are essential to improving prognosis.

trial registrationNot applicable.

Indexed as

Listeria monocytogenesListeriosisMeningitis, ListeriaMeningoencephalitisAdultAgedFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesClinical featuresListeria monocytogenesMeningoencephalitisNeuroimagingPrognosis

Identifiers

PMID41087940
PMCPMC12522386

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.