Evidence map›Paper›PMID 41087926›Full record

ArticleBMC genomic data2025

PAHG: the database of human multi-gene families.

Ramsha Azhar, Muhammad Faizan Malik, Rozeena Arif, Muhammad Waqas Khokhar, Yasir Mehmood Abbasi, Fatima Batool, Muhammad Haseeb Jalalzai, Yiming Bao, Amir Ali Abbasi

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Article in BMC genomic data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ramsha Azhar *National Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Muhammad Faizan Malik *National Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Rozeena ArifNational Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Muhammad Waqas KhokharNational Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Yasir Mehmood AbbasiNational Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Fatima BatoolNational Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Muhammad Haseeb JalalzaiComputer Science Department, Faculty of Computer Sciences, Quaid-i- Azam University, Islamabad, 45320, Pakistan.
Yiming BaoNational Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China. baoym@big.ac.cn.
Amir Ali AbbasiNational Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan. abbasiam@qau.edu.pk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the early vertebrate history, gene duplications, including single-gene, segmental-gene (SSD), and whole-genome duplication (WGD), formed multigene families. Despite efforts to classify metazoan multigene families hierarchically for evolutionary insight, a gap exists in accessible, curated resources for human/vertebrate multigene families.

resultsAddressing this, we present the Phylogenomic Analysis of Human Genome (PAHG) database. It focuses on curated multigene families in the human genome, particularly within four paralogons: HOX-bearing (Hsa:2/7/12/17), FGFR-bearing (Hsa:4/5/8/10), MHC-bearing (Hsa:1/6/9/19), and chromosomes 1/2/8/20.

conclusionThe current PAHG version details the phylogenetic history of 221 human multigene families (1247 gene members) with 15,231 protein sequences from diverse metazoans. It provides insights into gene duplication timings, co-duplication events, and their relationships with human genome syntenic organization. The PAHG database addresses the lack of accessible resources, offering valuable information on human/vertebrate multigene family evolution. Access the PAHG database at: https://www.pahgncb.com/ and http://pahg.qau.edu.pk/ . This resource enriches our understanding of vertebrate genetic evolution.

Indexed as

Databases, GeneticGenome, HumanMultigene FamilyAnimalsBiocurationEvolution, MolecularGene DuplicationHumansPhylogenyCuratedDatabaseData integrationDuplicationsHuman genomeMultigene familiesParalogonsPhylogenomics

Identifiers

PMID41087926
PMCPMC12522930

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