ArticleBMC immunology2025
Correlation between peripheral blood Th17/Treg immune imbalance and coronary artery lesions in children with Kawasaki disease.
Article in BMC immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- FOS regulation of T-cell activation and the mechanism of inflammatory injury of coronary endothelium in Kawasaki disease.Translational pediatrics · 2026Article
- Role of Programmed Cell Death in the Pathogenesis of Kawasaki Disease: Mechanisms and Therapeutic Implications.Mediators of inflammation · 2026Review
- Potential Mechanisms and Hypotheses for Pathogenic Microorganisms Triggering Kawasaki Disease.Clinical reviews in allergy & immunology · 2025Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCoronary artery lesions (CALs) are a specified feature of Kawasaki disease (KD), occurring in the second week of onset. The current study was to unravel the correlation between peripheral blood T helper 17/regulatory T (Th17/Treg) immune imbalance and CALs in children with KD.
methodsIn this cross-sectional study, 198 KD children were evaluated for their CALs as per the coronary arterial internal diameter, and allocated into the CAL and non-CAL groups, with their general baseline data and laboratory parameters collected. Peripheral blood Th17 and Treg were measured by flow cytometry, with Th17/Treg calculated. The correlations of peripheral blood Th17/Treg with the coronary arterial internal diameter and interleukin (IL)-6, the diagnostic value of neutrophil-lymphocyte ratio (NLR) and peripheral blood Th17/Treg for CALs, and the independent risk factors for CALs in KD children were analyzed by the Spearman’s, receiver operating characteristic curve and multivariate logistic regression analyses, respectively.
resultsNLR, C-reactive protein, IL-6, and Th17/Treg levels and percentage of anemia were higher in CAL children than in those with non-CAL (all P < 0.05). Peripheral blood Th17/Treg positively correlated with the coronary arterial internal diameter and IL-6 in CAL-KD children (all P < 0.001). Peripheral blood Th17/Treg > 71.56% had high diagnostic value for CALs in KD children (area under the curve: 0.856). Peripheral blood Th17/Treg was an independent risk factor for CALs in KD children (P < 0.05).
conclusionPeripheral blood Th17/Treg > 71.56% is effective in diagnosing CALs in KD children. Th17/Treg is an independent risk factor for CALs.
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