Effects of tranexamic acid in patients undergoing liver surgeries: an updated meta-analysis of randomized-controlled trials.

Mahmoud Kandeel, Mohamed Saad Sayed, Noof K Binashikhbubkr, Maryam Mahmoud

Abstract readMeta-AnalysisReview

In one paragraph

Synthesis in Updates in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mahmoud Kandeel *Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, 31982, Al-Ahsa, Saudi Arabia.

Mohamed Saad Sayed *Faculty of Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt. mohamedsaad271_sd@med.bsu.edu.eg.ORCID http://orcid.org/0009-0003-2713-3233

Noof K BinashikhbubkrCollege of Medicine and Health Sciences, Hadhramout University, Al Mukalla, Yemen.

Maryam MahmoudCollege of Medicine, Delta University for Science and Technology, Gamasa, 11152, Egypt.

Funding

King Faisal University KFU252851

6 · The paper itself

Abstract

Perioperative bleeding is a significant concern in hepatic surgeries, leading to increased morbidity, blood transfusions, and associated risks. Tranexamic acid (TXA) is effective in reducing blood loss in various surgical procedures, but its efficacy in liver surgeries remains uncertain. PubMed, CENTRAL, Web of Science, Embase, and Scopus were systematically searched without any automated filters through 20th October 2024. Continuous data were reported in mean difference (MD) with 95% confidence interval (95% CI), and dichotomous data were reported in odds ratio (OR) with 95% CI. STATA Corp M17 was used to analyze our outcomes. Six RCTs were analyzed, including 1,618 patients undergoing liver surgeries (resections or transplants). TXA did not significantly reduce the need for postoperative blood transfusion (OR 0.72; 95% CI [0.35-1.47], p = 0.37; I

Indexed as

Antifibrinolytic AgentsBlood Loss, SurgicalHepatectomyLiverPostoperative HemorrhageRandomized Controlled Trials as TopicTranexamic AcidBlood TransfusionHumansTreatment OutcomeAntifibrinolytic AgentsTranexamic AcidBlood transfusionLiverLiver surgeryMeta-analysisPerioperative bleedingTranexamic acidTXA

Identifiers

PMID41087824

DOI10.1007/s13304-025-02410-y

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.