Evidence map›Paper›PMID 41087820›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026

Cardiac oxidative damage and mitochondrial dysfunction induced by manganese deficiency are probably associated with the inhibition of the Nrf2 signaling pathway.

Haitao Xu, Wenhui Hou, Li Liu, Xin Wang, Yanlin Pu, Zheng Liu

Abstract read
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In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haitao XuDepartment of Health Management Center, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, 621000, Sichuan, China.
Wenhui HouDepartment of Health Management Center, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, 621000, Sichuan, China.
Li LiuDepartment of Health Management Center, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, 621000, Sichuan, China.
Xin WangSchool of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, 621010, Sichuan, China.
Yanlin PuDepartment of Health Management Center, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, 621000, Sichuan, China.
Zheng LiuDepartment of Cardiothoracic Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, 621000, Sichuan, China. lz20192024@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Manganese is an essential trace element for the human body, yet its role in heart function remains inadequately understood, this study aimed to reveal the influence of Mn deficiency on the heart, and uncover underlying mechanisms involved. A manganese-deficient diet was provided to weaned mice, to which manganese chloride (MnCl

Indexed as

ManganeseMitochondriaNF-E2-Related Factor 2Oxidative StressSignal TransductionAdenosine TriphosphateAnimalsChloridesMaleManganese CompoundsMiceMice, Inbred C57BLAdenosine TriphosphateChloridesManganesemanganese chlorideManganese CompoundsNfe2l2 protein, mouseNF-E2-Related Factor 2HeartMitochondriaMn deficiencyMouseOxidative stress

Identifiers

PMID41087820

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.