Evidence map›Paper›PMID 41087816›Full record

ArticlePharmacological reports : PR2025

Solcumin™: a functional hybrid particle with potent anti-inflammatory and antioxidant activities and enhanced storage stability.

Jinhee Jeong, Sujin Hwang, Chan Hee Lee, Chan Yang Lee, Byoung Seung Jeon, Jongwook Jeong, In-Soo Yoon, Dongwon Kim, Ee Taek Hwang

Abstract read
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Article in Pharmacological reports : PR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jinhee Jeong *Department of Cosmetics Engineering, Konkuk University, Seoul, Republic of Korea.
Sujin Hwang *ICBio Co., Ltd., Cheonan-si, Republic of Korea.
Chan Hee LeeEMbst Co., Ltd., Busan, Republic of Korea.
Chan Yang LeeKorea Institute of Ceramic Engineering and Technology, Osong, Republic of Korea.
Byoung Seung JeonKorea Institute of Ceramic Engineering and Technology, Osong, Republic of Korea.
Jongwook JeongDepartment of Food Biotechnology, Dong-A University, Busan, Republic of Korea.
In-Soo YoonDepartment of Manufacturing Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Republic of Korea.
Dongwon KimDepartment of Bio-Pharmaceutical Engineering, College of Bio-Health Convergence, Dongseo University, Busan, Republic of Korea. dwkim@gdsu.dongseo.ac.kr.
Ee Taek HwangDepartment of Food Biotechnology, Dong-A University, Busan, Republic of Korea. ethwang@dau.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeparation and encapsulation provide a practical and effective strategy for the targeted delivery of bioactive components in formulation technologies. This study aimed to develop an inorganic Pickering-mediated formulation, Solcumin™, for food-derived tetrahydrocurcumin (THC), and to evaluate its long-term storage stability and in vitro bioactivity.

methodsIn this study, we investigated the application of inorganic Pickering-mediated techniques to encapsulate food-derived bioactive compounds. Solcumin™ was industrially produced and subjected to physicochemical analysis, stability testing in distilled water over 8 weeks at 25 °C, and in vitro bioactivity assessment, including antioxidant (DPPH, ABTS), cytotoxicity (HDFn cells), and anti-inflammatory (NO, IL-6) assays.

resultsSolcumin™ contained 11.5% tetrahydrocurcumin (THC) and exhibited excellent stability in distilled water, retaining 85% of its initial THC content after 8 weeks of storage at 25°C, while effectively preventing leaching and oxidation. Furthermore, Solcumin™ demonstrated notable anti-inflammatory activity, inhibiting nitric oxide (NO) production by approximately 89.11% and reducing interleukin-6 (IL-6) expression in a dose-dependent manner. It also exhibited antioxidant activity, as indicated by radical scavenging activity in both 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays at a concentration of 100 µg/mL.

conclusionsTo the best of our knowledge, this is the first study to report the development of biomineralization-based Solcumin™ and evaluate its in vitro bioactivity.

Indexed as

Anti-Inflammatory AgentsAntioxidantsCurcuminAnimalsCell LineDrug StabilityDrug StorageHumansInterleukin-6Nitric OxideAnti-Inflammatory AgentsAntioxidantsCurcuminInterleukin-6Nitric OxidetetrahydrocurcuminBioactive compoundsCalcium carbonateFormulationFunctional powderInorganic pickeringTetrahydrocurcumin

Identifiers

PMID41087816

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.