Evidence map›Paper›PMID 41087750›Full record

ArticleNature neuroscience2025

Region-specific drivers of CSF mobility measured with MRI in humans.

Lydiane Hirschler, Bobby A Runderkamp, Andreas Decker, Thijs W van Harten, Paul Scheyhing, Philipp Ehses, Léonie Petitclerc, Julia Layer, Eberhard Pracht, Bram F Coolen and 13 more

Abstract read
In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. A conversation on human brain clearance.Nature communications · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Mapping subarachnoid cerebrospinal fluid circulation in the human brain.bioRxiv : the preprint server for biology · 2026
    Article
  10. Quantitative assessment of flow between cerebrospinal and interstitial fluid compartments in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. DRIPS: Domain Randomisation for Image-based Perivascular spaces Segmentation.medRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Lydiane HirschlerC.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands. l.hirschler@lumc.nl.ORCID http://orcid.org/0000-0003-2379-0861
Bobby A RunderkampDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0009-0007-5491-5379
Andreas DeckerGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Thijs W van HartenC.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-3408-9379
Paul ScheyhingGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Philipp EhsesGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Léonie PetitclercC.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Julia LayerGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0001-5904-5316
Eberhard PrachtGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Bram F CoolenDepartment of Biomedical Engineering and Physics, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Wietske van der ZwaagSpinoza Centre for Neuroimaging, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-3223-9721
Tony StöckerGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0002-8946-9141
Philipp VollmuthDivision for Computational Radiology & Clinical AI (CCIBonn.ai), Clinic for Neuroradiology, University Hospital Bonn, Bonn, Germany.
Daniel PaechDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-5755-6833
Alexander EfflandInstitute of Applied Mathematics, University Bonn, Bonn, Germany.
Marianne A A van WalderveenC.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Alexander RadbruchGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Mark A van BuchemC.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Gabor C PetzoldGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0002-0145-8641
Susanne J van VeluwC.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-7957-8643
Matthan W A CaanDepartment of Biomedical Engineering and Physics, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Katerina Deike *German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Matthias J P van Osch *C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-7034-8959

Funding

Alzheimer Nederland (Alzheimer Netherlands) WE.25-2020-05Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01KX2130Deutsche Forschungsgemeinschaft (German Research Foundation) EXC2151 - 390873048Else Kröner-Fresenius-Stiftung (Else Kroner-Fresenius Foundation) 2022_EKCS.17Else Kröner-Fresenius-Stiftung (Else Kroner-Fresenius Foundation) 2022-EKES.33Fondation Leducq 23CVD03
6 · The paper itself

Abstract

Many neurological diseases are characterized by the accumulation of toxic proteins in the brain. This accumulation has been associated with improper clearance from the parenchyma. Recent discoveries highlighted perivascular spaces, which are cerebrospinal fluid (CSF)-filled spaces, as the channels of brain clearance. The forces driving CSF mobility within perivascular spaces are still debated. Here we present a noninvasive, CSF-specific magnetic resonance imaging technique (CSF-Selective T

Indexed as

BrainCerebrospinal FluidGlymphatic SystemMagnetic Resonance ImagingAdultFemaleHumansMaleMiddle Aged

Identifiers

PMID41087750
PMCPMC12586159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.