Evidence map›Paper›PMID 41087727›Full record

ArticleNature immunology2025

Transient tissue residency and lymphatic egress define human CD56

Annika Niehrs, Laura Hertwig, Marcus Buggert, Isabella Nordström, Maura Statzu, M Betina Pampena, Sadia Samer, James J Knox, Benedikt Strunz, Dan Sun and 35 more

Abstract read
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. HIV controllers, lessons learnt from the lymphoid tissues.Current opinion in HIV and AIDS · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Annika NiehrsCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-2190-4346
Laura HertwigCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Marcus BuggertCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-0633-1719
Isabella NordströmCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Maura StatzuDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
M Betina PampenaDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6665-4865
Sadia SamerDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
James J KnoxDepartment of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3523-0661
Benedikt StrunzCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Dan SunCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2147-9308
Son NguyenDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0475-5158
Claudia JanoschkaDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Muenster, Germany.
Yafei XingCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Vincent H WuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8640-6065
Ernesto SparrelidDepartment of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Arlisa AlisjahbanaCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8400-8039
Yu GaoCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Natalie SleiersCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Otto StraussCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Iva FilipovicCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Andrea PonzettaCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-3224-802X
Itzel Medina-AndradeCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0009-0001-1625-4887
Vera NilsénCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Carl JornsDepartment of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7727-8113
Martin CornilletCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7981-0927
Christopher MaucourantCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Christoph ZiegenhainDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2208-4877
Julia HengstDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
George TweetCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Kyle KrollCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Gregory J GoldenDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4063-7116
Heiner WedemeyerDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Murat KürtüncüDepartment of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Yoav DoriDivision of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Maxim G ItkinDepartment of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Luisa KlotzDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Muenster, Germany.ORCID http://orcid.org/0000-0001-5439-9633
Marie SchafferCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Bo-Göran EriczonDepartment of Transplantation, Karolinska University Hospital, Stockholm, Sweden.
Martin A IvarssonCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Mirko PaiardiniDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-7276-3600
Greg NowakDivision of Transplantation Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8766-8860
Tim WillingerCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8720-7199
R Keith ReevesCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3157-2557
Michael R Betts *Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-7690-1484
Niklas K Björkström *Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. niklas.bjorkstrom@ki.se.ORCID http://orcid.org/0000-0002-0967-076X

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
ERASE HIV: Enterprise for Research and Advancements to Stop and Eradicate HIVUM1AI164562 · NIAID · EMORY UNIVERSITY · PI Deanna A Kulpa, Mirko Paiardini · 2021 to 2026
$30.0M
Viral Testing Core-Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research CenterU42OD011023 · OD · EMORY UNIVERSITY · PI Matthew Ryan Gardner · 2018 to 2026
$17.5M
Mechanisms of Natural Killer Cell Clearance of SIV from Lymphoid FolliclesR01AI143457 · NIAID · DUKE UNIVERSITY · PI REEVES, ROGER KEITH · 2019 to 2023
$3.1M
Cancerfonden (Swedish Cancer Society) CAN2017/418EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 948692European Molecular Biology Organization (EMBO) ALTF-999-2021Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) 4-3455/2016Kommunfullmäktige, Stockholms Stad (Stockholm City Council) 20190082NIAID NIH HHS R01 AI143457NIAID NIH HHS UM1 AI164562NIH HHS P51 OD011132NIH HHS U42 OD011023Novo Nordisk Fonden (Novo Nordisk Foundation) NNF14OC0009347Stiftelsen för Strategisk Forskning (Swedish Foundation for Strategic Research) FFL-0044Vetenskapsrådet (Swedish Research Council) 2020-06250
6 · The paper itself

Abstract

Human tissue-resident (TR) CD56

Indexed as

CD56 AntigenHomeostasisKiller Cells, NaturalLymph NodesAnimalsHumansMiceCD56 AntigenNCAM1 protein, human

Identifiers

PMID41087727
PMCPMC12571907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.