Observational studyEuropean journal of pediatrics2025
Computerized chest radiograph analysis of air distribution after surfactant treatment of respiratory distress syndrome in extremely preterm infants.
Observational study in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
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Abstract
The early air distribution after surfactant instillation can have implications for the development of lung injury in extremely preterm newborns with respiratory distress syndrome (RDS). The objective of this study is to determine lung air distribution and focal heterogeneity after surfactant treatment of RDS, using computerized image analysis of chest radiographs (CXRs). This is a retrospective observational non-paired study where CXRs were assessed within 6 h after surfactant instillation in the surfactant-treated group [STG] (n = 52; median 24
conclusionsIn this retrospective observational study of CXRs in extremely preterm infants, the right lungs were more aerated than the left lungs after surfactant, whereas the basal regions were more aerated than the apical regions regardless of surfactant treatment. We hypothesize that increased focal heterogeneity in these more aerated regions after surfactant may reflect overexpansion/atelectasis, which may be secondary to an inhomogeneous surfactant distribution, an observation that needs to be further validated in future studies. WHAT IS KNOWN: •Surfactant treatment has a major impact on survival in extremely preterm infants (EPIs) with respiratory distress syndrome (RDS), but less is known about the achieved early air distribution and its possible implications for future lung outcomes. WHAT IS NEW: •Computerized image analysis of plain chest radiographs (CXRs) provides more detailed information on the air distribution than clinical radiological grading whereby the optimal time point and administration techniques for surfactant instillation can be evaluated in EPIs with RDS.
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