Evidence map›Paper›PMID 41087614›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Longitudinal associations of body composition with sleep problems in the first two years after colorectal cancer treatment.

Ludovica Margotto, Eline H van Roekel, Marlou-Floor Kenkhuis, Stephanie O Breukink, Eric T P Keulen, Maryska L G Janssen-Heijnen, Ree Meertens, Matty P Weijenberg, Martijn J L Bours

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Comment on: "Longitudinal associations of body composition with sleep problems in the first two years after colorectal cancer treatment".Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ludovica MargottoDepartment of Epidemiology, GROW Research Institute for Oncology and Reproduction, Maastricht University, P.O. BOX 616, 6200 MD, Maastricht, The Netherlands.
Eline H van RoekelDepartment of Epidemiology, GROW Research Institute for Oncology and Reproduction, Maastricht University, P.O. BOX 616, 6200 MD, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-7758-7426
Marlou-Floor KenkhuisDepartment of Epidemiology, GROW Research Institute for Oncology and Reproduction, Maastricht University, P.O. BOX 616, 6200 MD, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-4199-4326
Stephanie O BreukinkDepartment of Surgery, GROW Research Institute for Oncology and Reproduction, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6229 HX, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-5445-4011
Eric T P KeulenDepartment of Internal Medicine and Gastroenterology, Zuyderland Medical Centre Sittard-Geleen, 6162 BG, Geleen, The Netherlands.ORCID http://orcid.org/0000-0001-6666-8773
Maryska L G Janssen-HeijnenDepartment of Epidemiology, GROW Research Institute for Oncology and Reproduction, Maastricht University, P.O. BOX 616, 6200 MD, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-3575-6070
Ree MeertensDepartment of Health Promotion, Care and Public Health Research Institute (CAPHRI), Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6200 MD, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-8424-9142
Matty P WeijenbergDepartment of Epidemiology, GROW Research Institute for Oncology and Reproduction, Maastricht University, P.O. BOX 616, 6200 MD, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-1695-4768
Martijn J L BoursDepartment of Epidemiology, GROW Research Institute for Oncology and Reproduction, Maastricht University, P.O. BOX 616, 6200 MD, Maastricht, The Netherlands. m.bours@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0002-5558-1258

Funding

Kankeronderzoekfonds Limburg, the Netherlands 00005739KWF Kankerbestrijding, the Netherlands UM2010-4867KWF Kankerbestrijding, the Netherlands UM2021-1/13387World Cancer Research Fund International 2017/1619World Cancer Research Fund International,United Kingdom 2016/1620
6 · The paper itself

Abstract

purposeSleep problems are a frequent concern of colorectal cancer (CRC) survivors. Research on modifiable lifestyle factors that may mitigate sleep problems is sparse. Therefore, we investigated how various body composition parameters are longitudinally associated with sleep problems from 6 weeks up to 24 months post-treatment.

methodsIn a prospective cohort of 396 stage I-III CRC survivors, home-based repeated measurements were conducted at diagnosis and at four post-treatment time points. The insomnia scale of the EORTC QLQ-C30 (range: 0-100) was used to measure sleep problems. Anthropometric measurements of adiposity (BMI, fat percentage, waist-hip ratio) and of muscle mass and muscle function (mid-upper arm muscle circumference, handgrip strength) were employed. Linear mixed models were applied to analyze overall longitudinal associations, and hybrid models were used to disentangle inter- and intra-individual components.

resultsAt 6 weeks post-treatment, 47.0% of participants reported sleep problems and symptom severity was at its highest; a decline was observed thereafter. In confounder-adjusted models, no statistically significant overall longitudinal associations of different body composition parameters with sleep problems were found. Intra-individual analyses revealed that increases in BMI were related to less sleep problems over time (β per 1 kg/m

conclusionsBMI increases in the first 24 months post-treatment were associated with decreased sleep problems. These findings must be interpreted with caution due to the observational design, yet might suggest a potential link between weight regain and sleep problems among CRC survivors recovering from the physical and mental impact of cancer treatment.

Indexed as

Body CompositionCancer SurvivorsColorectal NeoplasmsSleep Initiation and Maintenance DisordersAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesSeverity of Illness IndexBody compositionColorectal cancer survivorLongitudinalSleep problems

Identifiers

PMID41087614
PMCPMC12521294

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.