Evidence map›Paper›PMID 41087594›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Factors influencing serum uric acid levels and their impact on cardiovascular risk in patients with pediatric chronic kidney disease.

Myung Hyun Cho, Hee Gyung Kang, Yo Han Ahn, Seong Heon Kim, Eujin Park, Joo Hoon Lee, Jiwon Jung, Min Hyun Cho, Hee Sun Baek, Jae Il Shin and 6 more

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Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Myung Hyun ChoDepartment of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea.
Hee Gyung KangDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
Yo Han AhnDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
Seong Heon KimDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
Eujin ParkDepartment of Pediatrics, Korea University Guro Hospital, Seoul, South Korea.
Joo Hoon LeeDepartment of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea.
Jiwon JungDepartment of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea.
Min Hyun ChoDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South Korea.
Hee Sun BaekDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jae Il ShinDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea.
Keum Hwa LeeDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea.
Kyoung Hee HanDepartment of Pediatrics, College of Medicine, Jeju National University, Jeju, South Korea.
Heeyeon ChoDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Ji Yeon SongDepartment of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine, Yangsan, South Korea.
Ji Hyun KimDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea.
Eun Mi YangDepartment of Pediatrics, Chonnam National University Hospital, Chonnam National University School of Medicine, 42 Jebongro, Dong , Gwangju, 61469, Republic of Korea. emyang@chonnam.ac.kr.ORCID http://orcid.org/0000-0001-9410-5855

Funding

National Institute of Health (NIH) 2025E110100
6 · The paper itself

Abstract

backgroundElevated serum uric acid levels are commonly observed in chronic kidney disease (CKD) and are associated with cardiovascular disease (CVD). Research on the role of serum uric acid in pediatric CKD is limited. This study aims to investigate factors influencing serum uric acid levels and their association with CVD risk factors in children with CKD.

methodsWe used baseline data from the KoreaN cohort study for Outcome in patients with Pediatric Chronic Kidney Disease. Overall, 338 children with CKD were included.

resultsThe median age of participants was 9.8 years, and their mean estimated glomerular filtration rate (eGFR) was 63.5 mL/min/1.73 m

conclusionsIn pediatric CKD, higher serum uric acid levels were associated with male sex, older age, and lower eGFR, suggesting that these factors should be considered in clinical management. Additionally, the U-shaped relationship between serum uric acid levels and cardiovascular risk of hypertension and left ventricular hypertrophy underscores the importance of maintaining serum uric acid within an optimal range.

Indexed as

Cardiovascular DiseasesRenal Insufficiency, ChronicUric AcidAdolescentAge FactorsChildChild, PreschoolFemaleGlomerular Filtration RateHeart Disease Risk FactorsHumansHypertensionHypertrophy, Left VentricularMalePrevalenceRepublic of KoreaUric AcidCardiovascular diseaseChildChronic kidney diseaseHyperuricemiaUric acid

Identifiers

PMID41087594

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.