ArticleScientific reports2025
Resting state EEG reveals no reliable biomarkers of tinnitus laterality.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Fronto-temporal Delta-gamma Imbalance as a Neural Correlate of Hyperacusis in Tinnitus: An Exploratory EEG Study.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026Article
- Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects.Frontiers in aging neuroscience · 2026Review
- Electroencephalographic Biomarkers in Tinnitus: A Narrative Review of Current Approaches and Clinical Perspectives.Brain sciences · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
This study assessed whether resting-state quantitative EEG (qEEG) can differentiate tinnitus laterality under rigorous multiple-comparison control and nested, cross-validated machine learning (ML). We analyzed 210 pre-specified qEEG features-spectral power (n = 95), functional connectivity (n = 80), and hemispheric asymmetry indices (n = 35)-in 110 patients with chronic tinnitus (bilateral = 58, left = 27, right = 16, non-lateralized = 9). Group differences were tested with Kruskal-Wallis tests and Benjamini-Hochberg false discovery rate (FDR) correction (q < 0.05), followed by exploratory pairwise Mann-Whitney U tests and ANCOVA controlling for left-ear pure-tone average (PTA_L). No feature survived FDR in the four-group comparison. Although 48 features showed uncorrected p < 0.05 in at least one pairwise contrast, none remained significant after FDR. In the left-right contrast, effect sizes were small and post hoc power was low (< 30%). ANCOVA indicated that most apparent differences were attributable to hearing asymmetry: after adjustment, no features survived FDR, covariate effects were small (median partial η
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Registered trials
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