Evidence map›Paper›PMID 41087455›Full record

ArticleScientific reports2025

Hypoxia-driven circ-TBC1D1/miR-520h/EPHB4 impairs trophoblast function in unexplained recurrent spontaneous abortion.

Rong Hua, Qinshan Xie, Jiaxu Li, Yi Mo, Xiu Lin, Chun Huang, Min He, Fengqiong Liu, Yujie Huang, Jiangfan Wan and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rong Hua *Maternity and Child Health Care of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Qinshan Xie *Maternity and Child Health Care of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Jiaxu Li *Maternity and Child Health Care of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Yi Mo *The Reproduction Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Xiu LinThe Reproduction Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Chun HuangThe Reproduction Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Min HeThe Reproduction Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Fengqiong LiuThe Reproduction Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Yujie HuangThe Reproduction Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Jiangfan WanThe Reproduction Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Yan SunMaternity and Child Health Care of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. 2561611756@qq.com.

Funding

National Natural Science Foundation of China 82060286Natural Science Foundation of Guangxi Zhuang Autonomous Region 2019GXNSFAA185016
6 · The paper itself

Abstract

Hypoxia during early pregnancy critically regulates trophoblast function, and its dysregulation has been implicated in unexplained recurrent spontaneous abortion (URSA). This study investigated the circ-TBC1D1/miR-520 h/EPHB4 regulatory axis in HTR-8/SVneo trophoblast function under hypoxic conditions (2% O

Indexed as

Abortion, HabitualHypoxiaMicroRNAsReceptor, EphB4RNA, CircularTrophoblastsAdultApoptosisCell HypoxiaCell LineCell MovementCell ProliferationFemaleHumansPregnancyMicroRNAsMIRN520 microRNA, humanReceptor, EphB4RNA, CircularEPHB4Extravillous trophoblast cellsHypoxiaMiR-520 hUnexplained recurrent spontaneous abortion

Identifiers

PMID41087455
PMCPMC12521464

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.