Evidence map›Paper›PMID 41087441›Full record

ArticleScientific reports2025

Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons.

Marta Porniece, Jessica Baker, Charlotte D Ausfahl, Stephen X Zhang, Mark L Andermann

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Marta PornieceDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA.
Jessica BakerDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA.
Charlotte D AusfahlDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA.
Stephen X ZhangDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA. xz5184@nyu.edu.
Mark L AndermannDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA. manderma@bidmc.harvard.edu.

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI ROSEN, EVAN D · 1992 to 2021
$25.0M
Neuromodulatory mechanisms underlying vagus nerve stimulation therapy for Alzheimer's diseaseDP1AT010971 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANDERMANN, MARK L · 2019 to 2023
$6.6M
High-dimensional chemical targeting of multiple neuron types to regulate energy balanceDP1DK139958 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Mark L Andermann · 2024 to 2026
$2.4M
Neural Pathway Linking Nutritional State To Food-Cue Responses In Insular CortexR01DK109930 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANDERMANN, MARK L · 2016 to 2020
$2.2M
Competing effects of AgRP and POMC neurons on cAMP signaling in downstream neurons in vivoR00DK134853 · NIDDK · NEW YORK UNIVERSITY · PI Xingjie Zhang · 2025 to 2026
$495k
Competing effects of AgRP and POMC neurons on cAMP signaling in downstream neurons in vivoK99DK134853 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ZHANG, XINGJIE · 2023 to 2024
$182k
Deutsches Forschungsgemeinschaft PO 2925/1-1NCCIH NIH HHS DP1 AT010971NIDDK NIH HHS DP1 DK139958NIDDK NIH HHS K99 DK134853NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R00 DK134853NIDDK NIH HHS R01 DK109930NIH HHS K99 DK134853NIH HHS R01 DK109930
6 · The paper itself

Abstract

Melanocortin-4 receptor-expressing neurons in the paraventricular nucleus of the hypothalamus (PVH

Indexed as

Feeding BehaviorHypothalamusNeuronsObesityParaventricular Hypothalamic NucleusSatiety ResponseAnimalsDiet, High-FatEatingMaleMiceMice, Inbred C57BLReceptor, Melanocortin, Type 4SatiationReceptor, Melanocortin, Type 4

Identifiers

PMID41087441
PMCPMC12521569

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.