Evidence map›Paper›PMID 41087423›Full record

ReviewNPJ biofilms and microbiomes2025

Fusobacterium in the microbiome: from health to disease across the oral-gut axis and beyond.

Zhengrui Li, Ji'an Liu, Jing Li, Zhaokai Zhou, Xufeng Huang, Divya Gopinath, Peng Luo, Qi Wang, Dan Shan

Abstract readReview
In one paragraph

Review in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. The gut microbiota in malnutrition.Nature reviews. Microbiology · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Effects of dietary PQQ·NaPoultry science · 2026
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Pathogenic Roles ofPathogens (Basel, Switzerland) · 2026
    Review
  19. Apple Pomace Fermented with Non-International journal of molecular sciences · 2026
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhengrui Li *Department of Oral and Maxillofacial & Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ji'an Liu *Department of Oral and Maxillofacial & Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing Li *Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China.
Zhaokai Zhou *Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xufeng HuangFaculty of Dentistry, University of Debrecen, Debrecen, Hungary.
Divya GopinathBasic Medical and Dental Sciences Department, College of Dentistry, Ajman University, Ajman, UAE.
Peng LuoDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. luopeng@smu.edu.cn.
Qi WangDepartment of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. drwang71111@163.com.
Dan Shan *Faculty of Health and Medicine, Lancaster University, Lancaster, UK. d.shan@lancaster.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fusobacterium functions as both commensal and pathogen, linking the oral-gut axis to diverse diseases, including cancer. Evidence shows it modulates microbial balance, promotes dysbiosis, and contributes to carcinogenesis by driving inflammation, proliferation, invasion, and immune evasion. This review integrates ecological, molecular, and clinical insights, highlighting its roles in oral and systemic disease and discussing therapeutic potential, underscoring Fusobacterium's dualistic nature and implications for microbiome-targeted interventions.

Indexed as

FusobacteriumFusobacterium InfectionsGastrointestinal MicrobiomeMicrobiotaMouthAnimalsDysbiosisHumansNeoplasms

Identifiers

PMID41087423
PMCPMC12521585

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.