ArticleScientific reports2025
Comparison of interferon gamma release assays and tuberculin skin test performance for diagnosing Mycobacterium tuberculosis infection in the Pakistani population.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Data on clinical utility of IGRAs in BCG-vaccinated populations is limited. This cross-sectional study evaluated diagnostic performance of ELISPOT and ELISA-based IGRAs and compared them with conventional Tuberculin Skin Test (TST) for detecting Mtb infection in adult Pakistani population. Subjects (n = 325, age 18-64 years) recruited included active TB cases (n = 150), non-TB other pulmonary diseases patients (n = 50) and healthy individuals (n = 125). Two different IGRAs, X-DOT-TB (ELISPOT-based) and QFT-Plus (ELISA-based) were used to screen Mtb infection. Samples from 112/150 (74.7%) active TB patients, 10/50 (20.0%) non-TB other pulmonary diseases cases and 16/125 (12.8%) healthy individuals were X-DOT-TB positive, while 52.7% (29/55) active TB patients, 20.0% (4/20) non-TB other pulmonary diseases cases and 22.6% (12/53) healthy individuals tested by QFT-Plus had positive results. Sensitivity of X-DOT-TB and QFT-Plus was 79.5% (95%CI 77.4-81.5), and 55.7% (95%CI 52.9-58.5), respectively, significantly higher than TST 35.8% (95%CI 34.4-37.1, p < 0.05). Specificity of X-DOT-TB was 85.1% (95%CI 83.2-87.0), that of QFT-Plus was 78.1% (95%CI 75.3-80.9), comparable with TST specificity of 82.2% (95%CI 80.3-84.1, p > 0.05). IGRAs, particularly X-DOT-TB assay found to have greater sensitivity for detecting Mtb infection than TST. Our study suggests that IGRAs can be used as an adjunct diagnostic tool for detection of Mtb infection in BCG-vaccinated populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.