Evidence map›Paper›PMID 41087387›Full record

ArticleScientific reports2025

Serological surveillance of orally acquired acute Chagas disease in the Brazilian Amazon using conventional and in house assays.

Susan Smith-Doria, Jorge Augusto de Oliveira Guerra, Elsa Isela Guevara-Moctezuma, Emily de Sousa-Moura, Debora Raysa Teixeira de Sousa, Gabriela Maciel Alencar, Matheus Martins Monteiro, Jessica Vanina Ortiz, Yuliana Padrón-Antonio, Silvia Cassia Brandão Justiniano and 6 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Overview of Chagas disease in Amazonas: an integrated approach.Revista da Sociedade Brasileira de Medicina Tropical · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Susan Smith-DoriaPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil.
Jorge Augusto de Oliveira GuerraPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil.
Elsa Isela Guevara-MoctezumaPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil.
Emily de Sousa-MouraPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil.
Debora Raysa Teixeira de SousaPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil.
Gabriela Maciel AlencarPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil.
Matheus Martins MonteiroPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil.
Jessica Vanina OrtizPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil.
Yuliana Padrón-AntonioPrograma de Pós-graduação em Biodiversidade e Biotecnologia - Rede BIONORTE, Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.
Silvia Cassia Brandão JustinianoFundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT- HVD), Manaus - Amazonas, Brazil.
Lucely Paiva Rodrigues da SilvaPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil.
Alba Regina Jorge BrandãoPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil.
Katia do Nascimento CouceiroPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil.
João Marcos Bemfica Barbosa FerreiraPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil.
Adriano Gomes-SilvaLaboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil.
Maria das Graças Vale Barbosa GuerraPrograma de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Fundação de Medicina Tropical - Doutor Heitor Vieira Dourado (FMT-HVD), Manaus - Amazonas, Brazil. mgvale@uea.edu.br.

Funding

Fundação de Amparo à Pesquisa do Estado do Amazonas EDITAL N. 002/2018 - UNIVERSAL AMAZONASFundação de Amparo à Pesquisa do Estado do Amazonas EDITAL N. 010/2021- CT&I ÁREAS PRIORITÁRIAS
6 · The paper itself

Abstract

In the Brazilian Amazon, cases of acute Chagas disease (ACD) are mostly associated with the consumption of açaí juice contaminated with Trypanosoma cruzi have become frequent. A large proportion of diagnosed patients and exposed individuals after outbreaks are not followed-up clinically since they reside in the remote interior of the state of Amazonas with limited access to healthcare services. This study aims to conduct serological surveillance of populations exposed to T. cruzi in orally transmitted ACD. We evaluated 66 individuals with a history of diagnosis and treatment (G1), and 49 individuals without proven infection after exposure to outbreaks (G2). Serological surveillance was performed using 3 commercially available tests and 2 genotype-specific tests using antigens from T. cruzi strains TcI and TcIV. Among the G1, 34.8% presented serological cure whereas 6.1% in G2 presented seroconversion for IgG anti-T. cruzi while 22.5% (G2) had indeterminate results due to discordance between IIF and ELISA tests, which use different principles. Genotype-specific ELISA (TcI-TcIV) tests showed detection rates between 30.3 and 31.8% in G1, and 14.3-22.4% in G2. These results highlight the importance of follow-up serological surveillance among Amazonian populations exposed to ACD outbreaks. It also underscores the need for more sensitive serological tests with greater agreement for to ensure accurate diagnosis and monitoring of populations with a history of exposure.

Indexed as

Chagas DiseaseTrypanosoma cruziAcute DiseaseAdolescentAdultAgedAntibodies, ProtozoanBrazilChildEnzyme-Linked Immunosorbent AssayFemaleGenotypeHumansMaleMiddle AgedSerologic TestsAntibodies, ProtozoanELISAFollow upOral transmissionTrypanosoma Cruzi Tc I and TcIVWestern amazonWestern blot

Identifiers

PMID41087387
PMCPMC12521652

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.