ArticleNPJ science of food2025
Placental and cord blood DNA methylation in preterm birth: exploring the epigenetic role of maternal dietary protein.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02797327 (Molecular Signature of Karen and Burmese Pregnant Women on the Thailand-Myanmar Border), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular Signature of Karen and Burmese Pregnant Women on the Thailand-Myanmar Border
Who cites it
1 citing paper in PubMed.
- Cohort Profile: the SMRU Refugee and Migrant Pregnancy Study in Western Thailand and Eastern Myanmar.Wellcome open research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Emerging evidence suggests that maternal nutrition plays a critical role in fetal development and pregnancy outcomes. This study explores the epigenetic link between maternal nutrition and preterm birth (PTB) by analyzing DNA methylation (DNAm) in placental and cord blood samples from PTB and full-term pregnancies among Karen and Burmese populations in Myanmar and Thailand. Mothers who experienced PTB exhibited significantly lower intake of several nutrients, especially protein. DNAm profiling revealed hypomethylation of the LIPF promoter in placenta and hypermethylation of the SSB promoter in cord blood, with corresponding downregulation of SSB gene expression. Gene ontology analysis highlighted PTB-specific enrichment in inflammatory, developmental, and metabolic pathways, with cord blood notably enriched in genes involved in "embryo development ending in birth." Low protein intake correlated with SSB hypermethylation and differential methylation of IGKV1D-39. These findings provide novel insight into how protein deficiency may epigenetically predispose to PTB and suggest potential biomarkers for early detection and intervention. The clinical trial was registered on ClinicalTrials.gov registry, under NCT02797327, on 13-06-2016.
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Registered trials
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