ArticleNature communications2025
Catalyst-controlled stereodivergent synthesis of polysubstituted alkenes.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Programmable alkene skeleton construction via switchable radical and organometallic sorting.Nature chemistry · 2026Article
- Nickel-Catalyzed Boron-Mediated Saturative Trifunctionalization of Alkynes.Angewandte Chemie (International ed. in English) · 2026Article
- Enantioselective Trifunctionalization of Terminal Alkynes.Journal of the American Chemical Society · 2025Article
- Application of Asymmetric Catalysis in theJournal of the American Chemical Society · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
The strategic utilization of earth-abundant transition metals in catalysis has emerged as a trans-formative movement in advancing of synthetic chemistry. Despite notable progress, the potential of leveraging diverse geometric configurations of these catalysts to achieve divergent synthesis remains largely untapped. In this work, we present a stereodivergent three-component borylfunctionalization of alkynes, enabled by ligand-modulated geometric variations in nickel catalysts. This approach provides a versa-tile platform for the stereodivergent synthesis of two classes of valuable polysubstituted alkene building blocks, a challenging feat in organic synthesis. Its practical utility is showcased by the rapid construction of biologically relevant molecules. Mechanistic studies support that different geometric configurations of nickel catalysts display distinct reactivity during key reaction steps, leading to the observed stereochemical outcomes.
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Registered trials
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