Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Wei DaiDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA. wd157@dls.rutgers.edu.ORCID http://orcid.org/0000-0003-3032-3399
Funding
The Midwest Center for Cryo-Electron TomographyU24GM139168 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WRIGHT, ELIZABETH R · 2020 to 2025
$41.7M
Critical Factors Influencing Echinocandin Resistance in CandidaglabrataR01AI109025 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PERLIN, DAVID S · 2014 to 2025
$9.8M
Understanding the viscoelasticity, surface tension, and membrane interactions of biomolecular condensates in live cellsR35GM147027 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI Zheng Shi · 2022 to 2026
$1.6M
Novel machine learning approaches for improving structural discrimination in cryo-electron tomography-Administrative SupplementR01GM134020 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI XU, MIN · 2020 to 2023
$1.4M
A Bruker timsTOF HT mass spectrometer and nanoflow LC system to upgrade the proteomics facility at Rutgers-New Brunswick and Robert Wood Johnson Medical SchoolS10OD036226 · OD · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ZHENG, HAIYAN · 2024 to 2024
$1.1M
Micropipette-based quantification of neuronal protein condensates in live cellsR21DA056322 · NIDA · RUTGERS, THE STATE UNIV OF N.J. · PI SHI, ZHENG · 2022 to 2023
$392k
DOE | Advanced Research Projects Agency - Energy (Advanced Research Projects Agency - Energy - U.S. Department of Energy) DE-SC0019313National Science Foundation (NSF) DBI-2238093National Science Foundation (NSF) MCB-2046180NIAID NIH HHS R01 AI109025NIDA NIH HHS R21 DA056322NIGMS NIH HHS R01 GM134020NIGMS NIH HHS R35 GM147027NIGMS NIH HHS U24 GM139168NIH HHS S10 OD036226Rutgers, The State University of New Jersey Rutgers University Presidential Graduate FellowshipRutgers, The State University of New Jersey | Institute on Ethnicity, Culture, and the Modern Experience, Rutgers University (Clement A. Price Institute on Ethnicity, Culture, and the Modern Experience) Busch Biomedical GrantU.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R01AI109025U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R01GM134020U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R21DA056322U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R35GM147027
6 · The paper itself
Abstract
Fungal plasma membrane proteins represent key therapeutic targets for antifungal agents, yet their native structure and spatial distribution remain poorly characterized. Herein, we employ an integrative approach to investigate the organization of plasma membrane protein complexes in Candida glabrata, focusing on two abundant and essential membrane proteins, the β-(1,3)-glucan synthase (GS) and the proton pump Pma1. We show that treatment with caspofungin, an echinocandin antifungal that targets GS, disrupts the native distribution of membrane protein complexes and alters membrane biophysical properties. Perturbation of the sphingolipid biosynthesis further modulates drug susceptibility, revealing that the lipid environment plays an integral role in membrane protein organization and GS-echinocandin interactions. Our work highlights the importance of characterizing membrane proteins in their native context to understand their functions and inform the development of novel antifungal therapies.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Molecular landscape of the fungal plasma membrane and implications for antifungal action. · full record | OpenQuestion