Evidence map›Paper›PMID 41087234›Full record

ArticleAcademic radiology2026

Evaluating Stack-of-Stars and FLORET 3D Ultrashort Echo Time MRI to Assess Structural Pathology in Cystic Fibrosis Lung Disease.

Abdullah S Bdaiwi, Matthew M Willmering, Joseph W Plummer, Riaz Hussain, Laura L Walkup, Jason C Woods, Zackary I Cleveland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Academic radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abdullah S BdaiwiCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC-2021, Cincinnati, OH 45229 (A.S.B., M.M.W., J.W.P., R.H., L.L.W., J.C.W., Z.I.C.).
Matthew M WillmeringCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC-2021, Cincinnati, OH 45229 (A.S.B., M.M.W., J.W.P., R.H., L.L.W., J.C.W., Z.I.C.); Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio (M.M.W., L.L.W., J.C.W., Z.I.C.).
Joseph W PlummerCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC-2021, Cincinnati, OH 45229 (A.S.B., M.M.W., J.W.P., R.H., L.L.W., J.C.W., Z.I.C.); Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio (J.W.P., L.L.W., Z.I.C.).
Riaz HussainCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC-2021, Cincinnati, OH 45229 (A.S.B., M.M.W., J.W.P., R.H., L.L.W., J.C.W., Z.I.C.).
Laura L WalkupCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC-2021, Cincinnati, OH 45229 (A.S.B., M.M.W., J.W.P., R.H., L.L.W., J.C.W., Z.I.C.); Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio (M.M.W., L.L.W., J.C.W., Z.I.C.); Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio (J.W.P., L.L.W., Z.I.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (L.L.W., J.C.W., Z.I.C.).
Jason C WoodsCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC-2021, Cincinnati, OH 45229 (A.S.B., M.M.W., J.W.P., R.H., L.L.W., J.C.W., Z.I.C.); Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio (M.M.W., L.L.W., J.C.W., Z.I.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (L.L.W., J.C.W., Z.I.C.).
Zackary I ClevelandCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC-2021, Cincinnati, OH 45229 (A.S.B., M.M.W., J.W.P., R.H., L.L.W., J.C.W., Z.I.C.); Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio (M.M.W., L.L.W., J.C.W., Z.I.C.); Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio (J.W.P., L.L.W., Z.I.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (L.L.W., J.C.W., Z.I.C.). Electronic address: zackary.cleveland@cchmc.org.

Funding

UTE MRI to monitor CF lung disease and response to CFTR modulation in young childrenR01HL131012 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, JASON C WOODS · 2016 to 2026
$6.8M
Imaging and Molecular Phenotyping of Cystic Fibrosis Lung DiseaseR01HL151588 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I, ZIADY, ASSEM G · 2021 to 2025
$3.9M
Validating Quantitative Magnetic Resonance Imaging Biomarkers of Idiopathic Pulmonary FibrosisR01HL143011 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I · 2019 to 2023
$3.7M
Early detection of pulmonary complications of hematopoietic stem-cell transplantation in children using hyperpolarized xenon MRIR01HL166335 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Laura Lee Walkup · 2023 to 2026
$2.7M
NHLBI NIH HHS R01 HL131012NHLBI NIH HHS R01 HL143011NHLBI NIH HHS R01 HL151588NHLBI NIH HHS R01 HL166335
6 · The paper itself

Abstract

RATIONALE AND

objectivesFree-breathing structural lung MRI using 3D Ultrashort Echo Time (UTE) techniques has advanced substantially; however, image quality and diagnostic performance can vary depending on the acquisition strategy. Stack-of-Stars (SoS) is a commonly available UTE method, whereas FLORET (Fermat Looped, Orthogonally Encoded Trajectories) enables more efficient and isotropic k-space sampling. Thus, the purpose of this study was to compare the image quality and diagnostic performance of SoS and FLORET 3D UTE MRI in detecting structural lung abnormalities in individuals with cystic fibrosis (CF). MATERIALS AND

methodsSix individuals with CF (24.6 ± 7.3 years) underwent free-breathing lung MRI using multi-echo SoS for bronchiectasis T

resultsFLORET demonstrated significantly higher Sr (216 ± 60 vs 153 ± 76) and Cr (15.1 ± 5.2 vs 6.8 ± 9.6) than SoS (P < .001). Qualitative image scores were superior for FLORET across all domains. FLORET Brody scores correlated strongly with CT (R² = 0.95, κ = 0.94), while SoS showed weaker agreement (R² = 0.40, κ = 0.44). Inter-reader agreement was also higher with FLORET (R² = 0.70, κ = 0.82).

conclusionFLORET 3D UTE MRI provides superior image quality, improved diagnostic agreement, and stronger correlation with CT compared to SoS, supporting its use as a radiation-free alternative for structural assessment in CF lung disease.

Indexed as

Cystic FibrosisImage Interpretation, Computer-AssistedImaging, Three-DimensionalLungMagnetic Resonance ImagingAdolescentAdultFemaleHumansMaleReproducibility of ResultsYoung AdultFLORETLung imagingStack-of-starsStructural lung diseaseUltrashort echo time MRI

Identifiers

PMID41087234
PMCPMC13146095

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.