Evidence map›Paper›PMID 41087172›Full record

ArticleGenome research2025

Synergistic regulation by H3K36 and H3K27 methylation defines the chromatin landscape to control virulence and secondary metabolism in a fungal pathogen.

Xingmin Han, Chenghui Xu, Yiyi Ren, Meiling Guo, Jiayue Yan, Xuan Wang, Chao Liu, Qin Gu, Xing-Xing Shen, Zhonghua Ma and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xingmin HanState Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Department of Plant Protection, Zhejiang University, Hangzhou 310058, China.
Chenghui XuState Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Department of Plant Protection, Zhejiang University, Hangzhou 310058, China.
Yiyi RenState Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Department of Plant Protection, Zhejiang University, Hangzhou 310058, China.
Meiling GuoState Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Department of Plant Protection, Zhejiang University, Hangzhou 310058, China.
Jiayue YanState Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Department of Plant Protection, Zhejiang University, Hangzhou 310058, China.
Xuan WangState Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Department of Plant Protection, Zhejiang University, Hangzhou 310058, China.
Chao LiuState Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Department of Plant Protection, Zhejiang University, Hangzhou 310058, China.
Qin GuDepartment of Plant Pathology, College of Plant Protection, Nanjing Agricultural University, Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects, Ministry of Education, Nanjing 210095, China.
Xing-Xing ShenState Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Department of Plant Protection, Zhejiang University, Hangzhou 310058, China.
Zhonghua MaState Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Department of Plant Protection, Zhejiang University, Hangzhou 310058, China.
Yun ChenState Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Department of Plant Protection, Zhejiang University, Hangzhou 310058, China; chenyun0927@zju.edu.cn.ORCID 0000-0002-5663-2352

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histone methylation, catalyzed by SET domain-containing lysine methyltransferases, is a conserved epigenetic mechanism regulating gene expression in eukaryotes. However, the evolutionary dynamics of SET domain proteins and their functional interplay in fungi remain poorly understood. Here, we analyzed 18,718 SET domain proteins from 1038 fungal genomes and identified three major clusters, with Cluster 1 enriched for canonical histone methyltransferases. The evolution of the SET domain protein family coordinates with genome expansion in fungi. Functional characterization of seven Cluster 1 proteins in

Indexed as

ChromatinFusariumHistonesSecondary MetabolismEpigenesis, GeneticFungal ProteinsGene Expression Regulation, FungalGenome, FungalHistone-Lysine N-MethyltransferaseMethylationVirulenceChromatinFungal ProteinsHistone-Lysine N-MethyltransferaseHistones

Identifiers

PMID41087172
PMCPMC12581908

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.