Evidence map›Paper›PMID 41087171›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity.

Yulia Akbergenova, Jessica Matthias, Sofya Makeyeva, J Troy Littleton

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Yulia AkbergenovaDepartments of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 yulakb@mit.edu troy@mit.edu.
Jessica MatthiasAbberior Instruments America, Bethesda, Maryland 20814.ORCID 0000-0001-6560-2174
Sofya MakeyevaDepartments of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
J Troy LittletonDepartments of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 yulakb@mit.edu troy@mit.edu.ORCID 0000-0001-5576-2887

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Imaging Synaptic Transmission of Individual Active ZonesR01MH104536 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI J. TROY LITTLETON · 2014 to 2026
$4.7M
Molecular and Cellular Mechanisms Mediating Structural and Functional Active Zone MaturationR01NS117588 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LITTLETON, J. TROY · 2021 to 2025
$1.9M
NIH HHS P40 OD018537NIMH NIH HHS R01 MH104536NINDS NIH HHS R01 NS117588
6 · The paper itself

Abstract

Synapse formation requires the accumulation of cytomatrix proteins and voltage-gated Ca

Indexed as

Neuromuscular JunctionNeuronsPresynaptic TerminalsSynaptic TransmissionAnimalsAnimals, Genetically ModifiedCalcium ChannelsDrosophila melanogasterDrosophila ProteinsLarvaMaleBRP protein, DrosophilaCalcium ChannelsDrosophila Proteinsactive zoneDrosophilaneurotransmitter releaseNMJsynapsesynaptic vesicle fusion

Identifiers

PMID41087171
PMCPMC12660176

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.