ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
Hippocampal Ripples during Offline Periods Predict Human Motor Sequence Learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Hippocampal skill memory expansion drives online performance dynamics during skill learning.Cell reports · 2026Article
- Early skill learning is shaped by the offline emergence of expert synergies.Current biology : CB · 2026Article
- Neural Correlates of Motor Sequence Learning and Enhanced Offline Consolidation in 7-11-Year-Old Children.Human brain mapping · 2026Article
- Skill Memory Expansion Shapes Micro-Scale Dynamics of Skill Learning.bioRxiv : the preprint server for biology · 2026Article
- Expert Motor Synergies Emerge Predominantly Offline During Early Skill Learning.bioRxiv : the preprint server for biology · 2026Article
- Article
- Uncovering the Role of the Human Hippocampus in Procedural Motor Learning: Insights from Implicit Sensorimotor Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Impaired Online and Enhanced Offline Motor Sequence Learning in Individuals with Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-frequency bursts in the hippocampus, known as ripples (80-120 Hz in humans), have been shown to support episodic memory processes. However, converging recent evidence in rodent models and human neuroimaging suggests that the hippocampus may be involved in a wider range of memory domains, including motor sequence learning (MSL). Nevertheless, no direct link between hippocampal ripples and MSL has been established yet. Here, we recorded intracranial electroencephalography (iEEG) from the hippocampus in 20 epilepsy patients (11 males and 9 females) during an MSL task in which participants showed steady improvement across nine 30 s typing blocks interspersed with 30 s rest ("offline") periods. We first demonstrated that ripple rates strongly increased during rest relative to typing blocks. Importantly, ripple rates during rest periods tracked behavioral improvements, both across learning blocks and across participants. These findings suggest that hippocampal ripples during rest periods play a role in facilitating motor sequence learning.
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Registered trials
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