Evidence map›Paper›PMID 41087032›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2025

Roles of peripheral and central µ

Jianguo Zhuang, Xiuping Gao, Zikuan Chen, Shan Shi, Fadi Xu

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Carfentanil Depresses Inspiratory Motor Drive.Journal of substance abuse and alcoholism · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jianguo ZhuangDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, New Mexico, United States.
Xiuping GaoDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, New Mexico, United States.
Zikuan ChenDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, New Mexico, United States.
Shan ShiDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, New Mexico, United States.
Fadi XuDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, New Mexico, United States.ORCID 0000-0003-2345-3785

Funding

Mechanism and Countermeasure of Fentanyl-Induced Sudden DeathR01HL163512 · NHLBI · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI Fadi Xu · 2023 to 2026
$3.7M
Mechanism and Countermeasure of Carfentanil-induced Respiratory Disorder and DeathR01DA059063 · NIDA · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI XU, FADI · 2023 to 2025
$2.0M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL163512HHS | NIH | NIDA | National Drug Abuse Treatment Clinical Trials Network (CTN) DA059063NHLBI NIH HHS R01 HL163512NIDA NIH HHS R01 DA059063
6 · The paper itself

Abstract

Intravenous bolus (ivb) injection of fentanyl triggers a vagal-mediated immediate apnea and subsequent respiratory depression in anesthetized rats. This study compared the gender-dependence of these responses in conscious rats and roles of peripheral and central opioid receptors (ORs), especially µ- and mu1 opioid receptor (µ

Indexed as

FentanylReceptors, Opioid, muAnalgesics, OpioidAnimalsApneaFemaleHeart RateMaleNaloxoneNaltrexoneNarcotic AntagonistsRatsRats, Sprague-DawleyRespiratory InsufficiencyAnalgesics, OpioidFentanylnaloxonazineNaloxoneNaltrexoneNarcotic AntagonistsReceptors, Opioid, muCTAPmethylnaltrexone and naloxonazinenaloxonenaloxone methiodideopioid receptors

Identifiers

PMID41087032
PMCPMC12570114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.