ArticleJournal of advanced research2026
Preserved ratio impaired spirometry, plasma proteomics, and incident heart failure.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Inflammation-Metabolism Axis in Preserved Ratio Impaired Spirometry: Pathogenic Mechanisms and Translational Implications.Journal of inflammation research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEpidemiological evidence suggests the association of preserved ratio impaired spirometry (PRISm) at baseline with the risk of heart failure (HF), however, the associations between transitions of PRISm and incident HF remain to be clarified. Furthermore, the causal relationship and underlying biological mechanisms linking PRISm and HF are unclear.
objectivesThis study aimed to investigate the association between the normal-PRISm transition and incident HF, and further evaluate the causal relationship and underlying molecular mechanisms linking PRISm and HF.
methodsA total of 32,202 individuals with repeated spirometry and 40,047 individuals with proteomic data were included from the UK Biobank. Cox proportional hazards models were employed to estimate the association between the normal-PRISm transition and HF risk. Mendelian randomization (MR) analysis was performed to investigate the causal relationship between PRISm and HF. Mediation analysis was conducted to elucidate the mediation effects of 2,923 plasma proteins.
resultsCompared with consistent normal spirometry, the normal-PRISm transition was associated with an elevated risk of HF (hazard ratio: 1.814, 95 % CI: 1.128, 2.919). The MR suggested a causal link between PRISm and HF (odds ratio: 1.488, 95 % CI: 1.040, 2.130). In addition, 653 proteins demonstrated positive mediation effects, and the overall proteomic score mediated 59.63 % (95% CI: 46.98 %, 77.12 %) of the relationship between PRISm and HF.
conclusionIndividuals with the normal-PRISm transition were at an elevated risk of HF. The MR results suggested the causal link between PRISm and HF, and a variety of plasma proteins substantially mediated the relationship between PRISm and HF.
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