Evidence map›Paper›PMID 41086780›Full record

ArticleSchizophrenia research2025

The infraslow fluctuation of sigma power during sleep in young individuals with schizophrenia.

Maria E Dimitriades, Eve Schumacher, Janani Arudchelvam, Sara Fattinger, Salome Kurth, Fiona Pugin, Flavia Wehrle, Valeria Jaramillo, Carina Volk, Sven Leach and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Schizophrenia research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Maria E DimitriadesChild and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland; Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. Electronic address: maryeleni.dimitriades@kispi.uzh.ch.
Eve SchumacherChild and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland; Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Janani ArudchelvamChild and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Sara FattingerChild Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland; Center of Competence Sleep & Health Zurich, University of Zurich, Zurich, Switzerland.
Salome KurthCenter of Competence Sleep & Health Zurich, University of Zurich, Zurich, Switzerland; Department of Psychology, University of Fribourg, Fribourg, Switzerland.
Fiona PuginEudox Statistische Beratung, Basel, Switzerland.
Flavia WehrleChild Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland; University of Zurich, Zurich, Switzerland.
Valeria JaramilloChild Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland; Surrey Sleep Research Centre, University of Surrey, Guildford, UK; School of Psychology, University of Surrey, Guildford, UK; UK Dementia Research Institute Centre for Care Research & Technology, Imperial College London, London and University of Surrey, Guildford, UK.
Carina VolkChildren's Research Center, University Children's Hospital Zurich, Zurich, Switzerland; Center for MR Research, University Children's Hospital, University of Zürich, Switzerland.
Sven LeachChild Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Ashura BuckleySleep & Neurodevelopment Core, National Institute of Mental Health, Bethesda, MD, United States.
David I DriverChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, United States.
Andjela MarkovicDepartment of Psychology, University of Fribourg, Fribourg, Switzerland; Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Judith L RapoportChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, United States.
Leila TarokhTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Reto HuberChild and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland; Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.
Miriam GerstenbergChild and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. Electronic address: miriam.gerstenberg@pukzh.ch.

Funding

Childhood Onset SchizophreniaZIAMH002581 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI RAPOPORT, JUDITH L. · 2009 to 2017
$25.5M
Intramural NIH HHS ZIA MH002581
6 · The paper itself

Abstract

A well-replicated finding in schizophrenia is a reduction in sleep spindles, a major electrophysiological characteristic of Non-Rapid Eye Movement sleep. However, recent evidence indicates that even in healthy individuals, sleep spindles are not uniformly distributed throughout the night. Rather, they fluctuate rhythmically on an infraslow ∼50-second timescale, alternating between periods of high and low spindle activity. This fluctuation is referred to as the infraslow fluctuation of sigma power (10-16 Hz EEG activity, ISFS), which is modulated by noradrenergic activity from the locus coeruleus and seems to organize periods of arousability and periods of memory reactivation processes during sleep. Given the known deficit in sleep spindles, dysregulation of noradrenergic activity, and impairments in sleep maintenance and memory in schizophrenia, this study investigates the ISFS in sleep EEG data from individuals with either Childhood-Onset Schizophrenia (COS; N = 17) or Early-Onset Schizophrenia (EOS; N = 11), aged 9 to 21 years, alongside age- and sex-matched healthy controls (N = 56). The ISFS strength was reduced in both COS and EOS groups compared to controls, particularly in central-parietal electrodes. No significant difference in the ISFS strength was found between the two clinical groups, nor were there correlations between the ISFS strength and clinical characteristics or spindle density. These findings suggest that the ISFS is detectable but attenuated in young patients with schizophrenia, underscoring the value of considering spindle timing when probing disease mechanisms and designing interventions.

Indexed as

Brain WavesSchizophreniaSleepAdolescentChildElectroencephalographyFemaleHumansMaleYoung AdultAdolescenceChildhoodInfraslowSchizophreniaSigma powerSleepSleep spindles

Identifiers

PMID41086780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.